Abstract Blood contains hundreds of proteins, reflecting ongoing cellular processes and immune reactions. Infections with the blood-dwelling cardiopulmonary nematode Angiostrongylus vasorum in dogs manifest a broad spectrum clinical signs including respiratory distress, bleeding diathesis neurological signs, are associated perturbed blood protein profile dogs. However, current knowledge does no...

Blood and plasma proteins are heavily investigated as biomarkers for different diseases. However, the post-translational modification states of these rarely analyzed since blood contains many enzymes that rapidly remove modifications after sampling. In contrast to well-described role protein ADP-ribosylation in cells organs, its remains mostly uncharacterized. Here, we discovered phosphodiester...

When blood comes in contact with dialyzer membranes, the interfacial bioactivation reactions occurring at blood/membrane boundaries affect gross mechanisms related to thrombogenicity. In presence of biocompatible polymers, adhesion and subsequent interactions platelets, as well other serum components (e.g., proteins), are altered delay thrombus formation.

Background/Objective: Development of a new enzyme-linked immunosorbent assay (ELISA) for screening human blood serum and plasma for antibodies to human immunodeficiency virus type 1 (HIV1) and type 2 (HIV2) as HIV1/2REC ELISA diagnostic kit based on E. coli derived soluble recombinant proteins. Methods: Polypeptides corresponding to HIV1 gp41 and HIV2 gp36 immunodominant regions and HIV1 gag we...