Peptides patterned on the N-terminal sequence of fibronectin were synthesized and tested for amine acceptor qualities in reactions with dansylcadaverine catalyzed either by coagulation factor XIIIa or intracellular transglutaminase (protein-glutamine:amine gamma-glutamyltransferase, EC 2.3.2.13). On the basis of inverse half-saturations of the enzymes, the order of acceptor substrate affinity f...

Synthetic caspase inhibitors and particularly broad-spectrum caspase inhibitors can prevent cells from death or at least slow down cell death process and abrogate some apoptotic hallmarks [Kitanaka, C., Kuchino, Y., 1999. Caspase-independent programmed cell death with necrotic morphology. Cell Death and Differentiation 6, 508-515]. However, not all synthetic caspase inhibitors diminish cell dea...

Kinetic resolution of 2-arylindolines (2,3-dihydroindoles) was achieved by treatment their N-tert-butoxycarbonyl (Boc) derivatives with n-butyllithium and sparteine in toluene at −78 °C followed electrophilic quench. The unreacted starting materials together the 2,2-disubstituted products could be isolated high enantiomer ratios. Variable temperature NMR spectroscopy showed that rate Boc rotati...

Binary offset carrier (BOC) describes a class of spread-spectrum modulations recently introduced for the next generation of global navigation satellite systems (GNSSs). The design strategies of these BOC signals have so far focused on the spectral properties of these signals. In this paper, we present a time-domain fingerprint for each BOC signal given by a unique histogram of counted time elap...

The multipath effect is one of the main error sources in the Global Satellite Navigation Systems (GNSSs). The code correlation reference waveform (CCRW) technique is an effective multipath mitigation algorithm for the binary phase shift keying (BPSK) signal. However, it encounters the false lock problem in code tracking, when applied to the binary offset carrier (BOC) signals. A least-squares a...

The binary offset carrier (BOC) proposed for the global navigation satellite systems (GNSS) will enhance navigation performance and spectrum compatibility. However, the acquisition process is made more complex, due to the ambiguity in the autocorrelation function (ACF) of BOC. This paper proposes an unambiguous acquisition technique for the new cosine phased BOC (cosine-BOC) modulated signals, ...

BACKGROUND A "lectures plus clinical experiences" curriculum for surgical clerkships has significant faculty demand. A less faculty-intense blended online curriculum (BOC) could provide similar/improved academic performance compared with traditional curricula (TCs). METHODS Following an initial pilot study, students in the surgery clerkship at Johns Hopkins during 2013 to 2014 experienced a B...

LiTMP metalated dimethyl N-Boc-phosphoramidates derived from 1-phenylethylamine and 1,2,3,4-tetrahydronaphthalen-1-ylamine highly selectively at the CH3O group to generate short-lived oxymethyllithiums. These isomerized to diastereomeric hydroxymethylphosphonamidates (phosphate–phosphonate rearrangement). However, s-BuLi converted the dimethyl N-Boc-phosphoramidate derived from 1-phenylethylami...

Both energy band and charge separation and transfer are the crucial affecting factor for a photochemical reaction. Herein, the BiOCl nanosheets without and with surface bismuth vacancy (BOC, V-BOC) are prepared by a simple hydrothermal method. It is found that the new surface defect states caused by bismuth vacancy have greatly up-shifted the valence band and efficiently enhanced the separation...

BACKGROUND SPRINT-2 demonstrated that boceprevir (BOC), an oral hepatitis C virus (HCV) nonstructural 3 (NS3) protease inhibitor, added to peginterferon alfa-2b (P) and ribavirin (R) significantly increased sustained virologic response rates over PR alone in previously untreated adult patients with chronic HCV genotype 1. We estimated the long-term impact of triple therapy vs. dual therapy on t...