In spite of the impressive advances in the area of molecular pathology, bone marrow morphology remains the diagnosis cornerstone to identify the various subtypes of myeloid neoplasms. Morphological examination of the bone marrow requires both bone marrow aspirate and bone marrow trephine biopsy. Immunohistochemistry of bone marrow biopsy with markers reactive in paraffin-embedded tissues repres...

PURPOSE Bone marrow biopsy is a standard method for the evaluation of bone marrow infiltration by lymphoma; however, it is an invasive and painful procedure. Fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) is a noninvasive imaging technique with the potential to detect bone marrow involvement by lymphoma. MATERIALS AND METHODS We retrospectively reviewed medic...

Multiple myeloma is a malignant proliferation of plasma cells that typically presents in the bone marrow.Extramedullaryplasmacytoma (EMP) represents an unusual and characteristically progressive malignancythat can arise outside marrow. The occurrence multiple with plasmacytoma thelung very unusual. Herein, we report case lungdiagnosed by CT-guided FNAC marrow trephine biopsy. J MEDICINE 2022; 2...

A 73-year-old woman was referred to the hematology clinic for evaluation of anemia. Bone marrow biopsy revealed trilineage hematopoietic maturation with severe dyserythropoiesis. Laboratory studies showed a low copper level, and anemia resolved supplementation.

Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increa...

In order to determine whether antigenic patterns alter with disease progression and are thereby suggestive of impending blast crisis in chronic myelogenous leukemia. 50 bone marrow biopsy specimens from 32 patients were examined retrospectively using indirect immunoperoxidase labeling with three monoclonal antibodies that detect myeloid antigens. Monoclonal antibodies PMN1 3F6. PMN7C3. and PMN8...

Introduction Examination of bone marrow biopsy specimens is a valuable diagnostic procedure in patients with known or suspected lymphoproliferative disorders. ' A bone marrow biopsy specimen may be diagnostic in patients without lymphadenopathy or when there is no conclusive histological evidence from other sites. In some conditions, such as hairy cell leukaemia,2 it is the primary diagnostic p...

Studies have compared the role of bone marrow aspirate cytology and trephine biopsy for diagnosing various hematological disorders but fewer studies have compared the relative value of imprint cytology with aspirate and trephine biopsy. The present study was conducted to compare the role of bone marrow aspirate, touch imprint and trephine biopsy to formulate an effective and rapid method for di...

bone marrow is infrequently implicated in early stages of hodgkin’s disease. we studied the immunohistochemical bone marrow tissue of 7 out of 20 cases with early stage hodgkin’s disease of the mixed cellularity variant, diagnosed by lymph node biopsy at initial presentation, not responding to radiotherapy alone, in order to examine possible marrow attack. a statistically significant prevalence...