Graft-versus-host disease is a major complication for bone marrow transplant recipients and is often a cause of late mortality. It can affect any tissue, and involvement of the lungs--target organs of particular importance--can lead to chronic respiratory failure due to bronchiolitis obliterans. We report the case of a lung transplant in a woman who developed bronchiolitis obliterans after rece...

Abstract Background Prophylactic platelet transfusion is given to patients when the count less than ten thousand prevent clinically significant bleeding till engraftment documented. Despite a very low count, if confidently predicted, then can be avoided in an otherwise stable patient. Objective To determine role of post-transplant day + 14 immature reticulocyte fraction (IRF) and (IPF) as surro...

A number of malignant and nonmalignant medical problems, frequently in severely ill patients, demand for the advanced therapeutic technique known as a bone marrow transplant. To offer patients with high-quality care following transplants, nurses required knowledge practice.

Evidences from many studies suggested a polymerase chain reaction (PCR) as a valuable method for diagnosing infectious disease in the transplant recipients. We used this method for detection of Toxoplasma, gondii and human cytomegalovirus in blood specimens from patients after bone marrow or kidney transplantation. DNA of both infectious agents were detected using two separate sets of nested pr...

BACKGROUND AND AIMS In order to establish whether extraintestinal cells contribute to the turnover and repair of gastrointestinal tissues, we studied the colons and small intestines of female mice that had received a male bone marrow transplant, together with gastrointestinal biopsies from female patients that had developed graft versus host disease after receiving a bone marrow transplant from...

The International Bone Marrow Transplant Registry reported experience from 179 transplant teams worldwide on patients treated with bone marrow transplantation for severe aplastic anemia. The cohort consisted of 470 patients (283 male, 187 female), mean age 20 years, who received an HLA-identical sibling bone marrow transplant for aplastic anemia between 1988 and 1992. The etiology of aplastic a...

Bone marrow transplantation can be complicated by renal failure resulting from a variety of causes. Early renal injury most often results from infection and its subsequent treatment with nephrotoxic medications. Late renal injury after bone marrow transplantation is characterized by a syndrome similar to the hemolytic uremic syndrome. This renal syndrome, called “bone marrow transplant nephropa...

The aim of our study was to investigate the role of bone marrow cells in the phenotypic changes that occur in diabetic nephropathy. Bone marrow cells were obtained from either streptozotocin-induced diabetic or untreated control C3H/He mice and transplanted into control C3H/He mice. Eight weeks after bone marrow cell transplantation, renal morphologic changes and clinical parameters of diabetic...

background: chronic graft versus host disease (cgvhd) is one of the most serious potential complications of allogeneic bone marrow transplantation. study design and method: we analyzed the incidence of cgvhd and its associated risk factors in a group of 161 iranian recipients of hla-identical sibling transplants, with at least 90 days post-transplantation survival. in the majority of cases (n=7...