background: bone morphogenetic proteins (bmps) belong to the transforming growth factor-β (tgf-β) superfamily, and play an important role in bone metabolism. recombinant forms of bmp-2 and bmp-7 are the only bmps used clinically. in this study the mature part of human bone morphogenetic protein-7 (bmp-7) was engineered through substitution of the bmp-7 n-terminal sequence by heparin-binding sit...

Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-? superfamily. Initially discovered for their ability induce bone formation, BMPs known play diverse and critical array biological roles. We here focus on recent evidence showing BMP4 is an important regulator white/beige adipogenic differentiation with consequences thermogenesis, energy homeostasis, de...

Bone Regeneration In article 2201886 by Huaqiong Li and co-workers, human hair keratin is proposed as an organic binder for the simultaneous incorporation of bone's major inorganic component, hydroxyapatite, growth factor, recombinant bone morphogenetic protein 2 (rhBMP2), to enable both osteoconductive osteoinductive characteristics in creation scaffolds.

Neocortical neurons begin to differentiate soon after they are generated by mitoses at the surface of the ventricular zone (VZ). We provide evidence here that bone morphogenetic protein (BMP) triggers neuronal differentiation of neocortical precursors within the VZ. In cultures of dissociated neocortical neuroepithelial cells, BMPs increase the number of MAP-2- and TUJ1-positive cells within 24...