Hemangioendothelioma is a rare neoplasm of bone that uncommonly involves the skull. We present a case of grade III malignant hemangioendothelioma (also known as angiosarcoma) of the skull in a 13-year-old boy and describe the plain film, CT, and MR appearance of this neoplasm as well as its histopathology.

central cementifying fibroma is a bony tumor, which is believed to be derived from the cells of the periodontal ligament. central cemento‑ossifying fibroma behaves like, a benign bone neoplasm. this bone tumor consists of highly cellular, fibrous tissue that contains varying amounts of calcified tissue resembling bone, cementum, or both. central cemento‑ossifying fibromas of the mandible are co...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive myeloid neoplasm derived from plasmacytoid monocytes. The most common presentation involves cutaneous manifestations, which are often accompanied by bone marrow involvement. The tumor cells reveal an immature blastic appearance and diagnosis is based on the expression of cluster of differentiation (CD)4 and CD56. The literatu...

Langerhans cell histiocytosis (LCH) is a rare neoplasm defined as the proliferation of bone marrow langerhans cells, which is a kind of dendritic cells. The major pathological features of LCH are expression of CD1a and S100 as well as Birbeck granules. Its presentation can differ from a mild bone lesion to a multi-systemic evolved malignant neoplasm; however, the latter outcome is almost rare. ...

Primary perivascular epithelioid cell tumor neoplasm (PEComa) of bone is extremely rare. To our knowledge, only 11 cases of PEComa primarily arising in bone have been described. Herein, we present one case of primary bone PEComa which occurs in the thigh.

Background: Understanding the differences in genetics of malignancies is crucial for therapeutic decisions. This systematic review was conducted to evaluate the current evidence on genetics of bone tumors in the context of pediatric cancer. Material and Methods: We performed a systematic review of the literature published on genetics of pediatrics bone tumors, using PubMed, Google scholar,...

A benign bone neoplasm known as an osseous fibroma is frequently referred fibro-osseous lesion. It has a stronger preference for females and thought to have originated from periodontal membrane. Maxilla less often afflicted than the mandible. This made up of highly cellular, fibrous tissue with varied levels calcified tissue, which may resemble cementum, bone, or both. Depending on degree calci...

8p11 myeloproliferative syndrome (EMS) is a very rare clinicopathological entity which is characterized by the appearance of a myeloproliferative neoplasm in the bone marrow, peripheral lymphadenopathy, usually caused by T or B lymphoblastic lymphoma/leukemia, and a reciprocal translocation involving chromosome 8p11. Herein we describe a 22-year-old male patient with unusual clinical presentati...

| 6 | haematologica | 2008; 93(1) Current classification and diagnosis of systemic mastocytosis, and its distinction from other myeloid malignancies associated with bone marrow mastocytosis, remain challenging for both clinicians and hematopathologists. In its upcoming revision, due out in 2008, the World Health Organization (WHO) classification system for myeloid malignancies considers mast ce...

We describe the first definitive case of a fibrous dysplastic neoplasm in a Neandertal rib (120.71) from the site of Krapina in present-day Croatia. The tumor predates other evidence for these kinds of tumor by well over 100,000 years. Tumors of any sort are a rare occurrence in recent archaeological periods or in living primates, but especially in the human fossil record. Several studies have ...