BACKGROUND This study was designed to assess whether preoperative trigger-site confirmation using botulinum toxin type A injections significantly improved migraine surgery outcomes. METHODS The medical charts of 335 migraine surgery patients were reviewed. Patients who received stepwise diagnostic botulinum toxin type A injections were placed in the botulinum toxin type A group (n = 245). Pat...

flushing is a condition with episodic attacks of redness of the skin with a sensation of warmth or burning, this disease causes emotional and functional problems in patients. there is various treatments for this condition; one of them is the use of botulinum toxin-a (bta). in this prospective pilot study we studied the effect of botulinum toxin-a (bta) effect on dlqi of patients with facial flu...

among the therapeutic options for achalasia are pneumatic dilatation (pd), an appropriate long-term therapy, and botulinum toxin injection (bt) that is a relatively short-term therapy. this study aimed to compare therapeutic effect of repetitive pneumatic dilation with a combined method (botulinum toxin injection and pneumatic dilation) in a group of achalasia patients who are low responder to ...

botulinum toxin produced by clostridium butolinum in one of the most fatal toxins known. botulism is the name given to condition produced by this toxin. in recent years the diluted form of this toxin has been produced in injection form and used for treatment of hemifacial spasm and blepharospasm. this toxin blocks neuromuscular junction and inhibits acetylcholine release. in this article we rep...

Botulinum toxin is an injectable neuromodulator derived from neurotoxins produced by the bacterium Clostridium botulinum, which causes botulism. The human face made up of a complex network muscles that work together to create facial expressions and perform essential functions. Clinicians who understand anatomy functional relationships between in neck can use botulinum safely selectively weaken ...

Objectives: The aim of this work was to determine the effect of small doses (5U) of botulinum toxin A (BTA) injected directly into the painful trigger points of the muscles. Methods: 42 patients suffering from myofascial pain in the neck-shoulder region were studied. The patients received either botulinum toxin A or physiological saline injections on 3 occasions 6 weeks apart. The total dose va...

conclusions the evidence that btx-a decreases ntg-induced cgrp-li and sp-li levels in trigeminovascular system suggests that btx-a attenuates migraine by suppression of neuropeptide release. btx-a injections for migraine at acupoint-sites and fixed-sites are effective. acupoint-sites btx-a administration shows more efficacy for migraine than fixed-sites application. results local btx-a injectio...

The binary botulinum C2 toxin ADP-ribosylated the actin of human neutrophils. Treatment of human neutrophils with botulinum C2 toxin for 45 min increased FMLP-stimulated superoxide anion (O2-) production 1.5-5-fold, whereas only a minor fraction of the cellular actin pool (approximately 20%) was ADP-ribosylated. Effects of botulinum C2 toxin depended on toxin concentrations, presence of both co...