Hypoxia is well known to cause an increase in brain anaerobic glycolysis. Ornithine alpha ketoglutarate (OAKG) given to six dogs was shown to attenuate these metabolic disturbances caused by hypoxia. Brain oxygen utilization was higher after ornithine alpha ketoglutarate during hypoxia than during a period of hypoxia alone. It is suggested that the clinical usefulness of OAKG should be explored...

Abstract Background Hypoxia-mediated radioresistance is the main obstacle to successful treatment of glioblastoma (GBM). Enhancing hypoxic radiosensitivity and alleviating tumor hypoxia are both effective means improve therapeutic efficacy, combination two highly desirable meaningful. Results Herein, we construct a low-dose pleiotropic radiosensitive nanoformulation consisting high-Z atomic nan...

Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates. Here we describe our current work investigating how the serotonergic network in the...

Acute cerebral hypoxia causes rapid calcium shifts leading to neuronal damage and death. Calcium channel antagonists improve outcomes in some clinical conditions, but mechanisms remain unclear. In 18 healthy participants we: (i) quantified with multiparametric MRI the effect of hypoxia on the thalamus, a region particularly sensitive to hypoxia, and on the whole brain in general; (ii) investiga...

Aims: Microvascular alterations occurring after myocardial infarction (MI) may represent a risk factor for multi-organ failure. Here we used in vivo photoacoustic (PA) imaging to track and define the changes vascular oxygen saturation (sO 2 ) over time experimental MI multiple peripheral organs brain. Methods Results: Experimental was obtained BALB/c mice by permanent ligation of left anterior ...

Ischemic stroke (IS) occurs as a result of local disturbance hemocirculation and hypoxia in the brain tissue. Hypoxia-inducible factor-1α (HIF-1α), which is involved regulation tissue oxygen levels, plays an important role pathophysiology stroke, including neuronal survival, neuroinflammation, angiogenesis, glucose metabolism, blood-brain barrier permeability, IS outcomes. The purpose study was...

Abstract Glioblastoma (GBM) is a malignant brain tumor with poor prognosis that easily recurs. The antiangiogenic agent bevacizumab used to treat recurrent GBM. However, GBM treated rebounds due evasive mechanisms induce resistance treatment, such as hypoxia‐inducible factor (HIF) associated pathways. transcription HIFs are oxygen‐dependent and degraded via the ubiquitin‐dependent proteasomal p...

BACKGROUND Brain injuries induced by hypoxia-ischemia in neonates contribute to increased mortality and lifelong neurological dysfunction. The specific PKR inhibitor C16 has been previously demonstrated to exert a neuroprotective role in adult brain injuries. However, there is no recent study available concerning its protective role in hypoxia-ischemia-induced immature brain damage. Therefore, ...

Late-gestational intrauterine hypoxia represents a well-known risk factor of acquired perinatal brain injury. Cell type and age-specific sensitivity of hypoxia-responsive genes to low-oxygen partial pressure is to be considered in the screening for early indicators of fetoplacental tissue hypoxia. To identify early hypoxia-induced alterations in gene expression during late-gestational hypoxia (...