introduction: gamma knife is an instrument specially designed for treating brain disorders. in gamma knife, there are 201 narrow beams of cobalt-60 sources that intersect at an isocenter point to treat brain tumors. the tumor is placed at the isocenter and is treated by the emitted gamma rays. therefore, there is a high dose at this point and a low dose is delivered to the normal tissue surroun...

background and importance: the coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated. case presentation: two cases of concomitant sellar and suprasellar region tum...

objective(s): in order to grow cells in a three-dimensional (3d) microenvironment, self-assembling peptides, such as puramatrix, have emerged with potential to mimic the extracellular matrix. the aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

objective(s): the study objective was to assess the diagnostic performance of positron emission tomography (pet) for gliomas using the novel tracer 18f-fluciclovine (anti-[18f]facbc) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.methods: anti-[18f]facbc was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by pet...

background and purpose: cancer and cerebrovascular accidents (cva) are two most common causes of mortality and morbidity in the elderly. patients with brain tumor can be highly affected by postsurgical stroke. cva may be the first manifestation in these patients . therefore, we aimed to assess the epidemiological factors affecting cva after brain surgery. methods: in this cross-sectional study ...

purpose: this study was conducted to assess cognitive impairments, depression, anxiety and quality of life among patients with brain tumor and healthy adults, comparatively. methods: a cross-sectional study was administrated on 84 brain tumor patients and 84 healthy adults measured by the mini mental state examination, beck, hamilton and sf36 questionnaires before and after 10 days of surgery. ...

 Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...

Introduction: The brain tumor is an abnormal growth of tissue in the brain, which is one of the most important challenges in neurology. Brain tumors have different types. Some brain tumors are benign and some brain tumors are cancerous and malignant. Glioblastoma Multiforme (GBM) is the most common and deadliest malignant brain tumor in adults. The average survival rate for peo...

Introduction: 99mTc-MIBI has been proposed for use as an imaging agent for various tumors, including breast cancer, lung cancer, lymphomas, melanomas and brain neoplastic lesions. Brain tumors are very common and radiotherapy being major part of treatment following surgery. After radiotherapy, deteriorating clinical status can be due to either radiation necrosis or recurrent tumor. Comput...

In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s,  Mahaley used monoclonal antibodies to treat central nervous system(CNS)  tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...