نتایج جستجو برای: breast cancerous tissues
تعداد نتایج: 438636 فیلتر نتایج به سال:
Quantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate the conventional X-ray mammography, where the projection of displacement information is acquired instead of full three-dimensional (3D) vector. The elastic parameters of normal ...
Target molecules for a highly sensitive and specific diagnosis of breast cancer in its early clinical stages have not yet been identified. Here, we show the first evidence for diagnostic performance of the molecule B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) in breast cancer patients. Only 5 out of 46 non-cancerous samples were positive for Bmi-1 mRNA expression res...
The reports provided by OMS in 2011 have showed that cancer is a major cause of death in the world, causing 7.6 million deaths in 2008. Breast cancer is in the world, the most common neoplasia of women, and it appears that low penetrance genes, but frequently mutated in the general population play an important role in the development of this cancer. The objective of this study is to evaluate th...
Background & Objective: Malignant breast tumors, which are one of the most important deadly cancers in women, like many other cancers, are proposed to be related to viruses etiologically. Proper management of breast carcinoma necessitates an identification of the etiological factors. Human Papillomavirus is considered to have an etiological role in breast carcinoma. We...
BACKGROUND Methyl sulfone is a small molecule that reverses cancerous phenotypes of a melanoma cell line. Here, we sought to determine whether methyl sulfone was effective against human breast cancer tissue. METHODS We studied normal and cancerous breast tissue obtained from 17 patients. RESULTS Methyl sulfone introduced structural order, with cancer tissue taking on the morphology of norma...
Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated t...
In this work, optical scattering using Raman spectroscopy has been analyzed for various cancer tissues. The Raman shifts obtained at the Indiana University Bloomington (IUB) and Indiana University-Purdue University Indianapolis (IUPUI) laboratories have been processed for diagnosing various types of cancer tissues. The objective of this research is to distinguish between cancerous and non-cance...
Breast cancer is the most common cause of cancer death among women under age 50 years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of this disease. Here, we present a new approach for the identification of breast cancer markers that does not measure gene expression but instead uses the ratio of alternatively spliced mRNAs as its indicator. Using a high-t...
BACKGROUND AND PURPOSE L1 cell adhesion molecule (L1CAM) has been observed to be aberrantly expressed and implicated in progression of several types of human cancers. However, its roles in breast cancer have not been fully elucidated. In this study, we aimed to investigate the clinical significance of L1CAM in human breast cancer and to validate whether it participates in cancer cell migration ...
The Viscoelastic response of hydropolymers, which include gelatin phantom and glandular breast tissue, may be accurately characterized with as few as three parameters using the Kelvin-Voigt Fractional Derivative (KVFD) modeling approach. We propose to image these parameters for simulated and experimental imaging phantoms and to estimate them for normal and cancerous in-vivo breast tissues. Afte...
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