The volume is dedicated to novel anticancer strategies. Our aim was to identify and cover novel, emerging anticancer approaches that will form the backbone of future, more efficient anticancer therapies. Beside classical "small molecule" pharmacologic approaches, or radiotherapy, the review introduces cancer stem cell, their markers involved in metastasizing, it covers various immunotherapeutic...

Classical chemotherapy, that spocifically targets rapidly proliferating cells, has been in existence for over eighty yeors and has proven to be fully successful in only a limited number of cancers. Thus, this review focuses on a novel, emerging approach for cancer therapy that uses alternative, a nd more unique features of cancer cells. This new approach faci litates the seloctive targeting of ...

Antimicrobial peptides in the skin secretions of anurans constitute a component of the innate immunity that protects the organism against invading pathogens. Four peptides with antimicrobial activity were isolated in high yield from norepinephrine-stimulated skin secretions of the Northern red-legged frog Rana aurora aurora and their primary structures determined. Ranatuerin-2AUa (GILSSFKGVAKGV...

Generalizing our recent joint paper with Vasily Pestun (arXiv:2001.04929), we construct a family of $SO(2r),Sp(2r),SO(2r+1)$ rational Lax matrices, polynomial in the spectral parameter, parametrized by divisors on projective line coefficients being dominant integral coweights associated Lie algebras. To this end, provide RTT realization antidominantly shifted extended Drinfeld Yangians $\mathfr...

It is known that there a correspondence between representations of superalgebras and ordinary (non-graded) algebras. Keeping in mind this type the twisted quantum affine superalgebra Uq(gl(2r|1)(2)) non-twisted algebra Uq(so(2r+1)(1)), we proposed, previous paper [1], Wronskian solution T-system for Uq(so(2r+1)(1)) as reduction (folding) Uq(gl(2r|1)(1)). In paper, elaborate on solution, give pr...

Antimicrobial peptides (AMPs) are considered potential alternatives to antibiotics due their advantages in solving antibiotic resistance. Brevinin-2GUb, which was extracted from the skin secretion of Hylarana guentheri, is a peptide with modest antimicrobial activity. Several analogues were designed explore structure–activity relationship and enhance its In general, Rana box not an indispensabl...

BACKGROUND Many species of frogs secrete cutaneous antimicrobial peptides that are capable of killing Batrachochytrium dendrobatidis. Some of these species are nonetheless susceptible to chytridiomycosis, suggesting that host factors causing dysregulation of this innate immune response may be important in pathogenesis. Since stresses, such as from environmental perturbations, are a potential ca...