نتایج جستجو برای: bromocriptine

تعداد نتایج: 1198  

Journal: :International journal of basic and clinical pharmacology 2021

Background: Diabetes mellitus is a chronic metabolic disorder that develops due to insulin deficiency or resistance. Recent animal and human studies have reported bromocriptine be effective in the management of type 2 diabetes mellitus. The present study was done evaluate antihyperglycemic effect dexamethasone induced hyperglycemic rats.Methods: Male wistar rats were used divided into 5 groups....

Journal: :Hypertension 2001
F Franchi C Lazzeri G Barletta L Ianni M Mannelli

Bromocriptine, a dopamine agonist, is known to lower cardiovascular mortality in L-dopa-treated patients with Parkinson's disease, probably by reducing the cardiac sympathetic activity. We aimed at unmasking the central effects of bromocriptine on the heart by power spectrum analysis. Ten healthy subjects (aged 31+/-2 years) in supine and sitting positions were evaluated after the administratio...

Journal: :The European respiratory journal 1997
G Hillerdal J Lee A Blomkvist A Rask-Andersen M Uddenfeldt H Koyi E Rasmussen

Bromocriptine, which is used in the treatment of Parkinson's disease, can cause adverse pleuropulmonary reactions. Exposure to asbestos can result in similar lesions. Fifteen patients with former exposure to asbestos, who developed pleural fibrosis after treatment with bromocriptine, were observed independently in Sweden (11 patients) and Australia (four patients). The patients complained of ma...

Journal: :The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1987
R J Riopelle

As the direct agonist with the widest clinical use, bromocriptine provides a unique window into the clinical spectrum of Parkinson's disease. The efficacy of bromocriptine for therapy of de novo Parkinson's disease has recently been confirmed using a double-blind design with L-Dopa (Sinemet). Over a period of 5.5 months, bromocriptine was found to be as effective as L-Dopa in reducing the funct...

Journal: :Molecular and cellular endocrinology 2014
Qiang Li Zhipeng Su Jie Liu Lin Cai Jianglong Lu Shaojian Lin Zhengkun Xiong Weiqiang Li Weiming Zheng Jinsen Wu Qichuan Zhuge Zhebao Wu

Bromocriptine, a dopamine agonist (DA), has been used in the treatment of prolactinomas. Recent studies have indicated that dopamine 2 receptor short isoform (D2S) may play an important role in suppressing PRL synthesis and prolactinoma cell growth under DA treatment. In the current study, we investigated the role of D2S in the therapeutic action of bromocriptine in GH3 using both in vitro and ...

2012
Xiangting Chai Qiaoyu Liu Wenyu Shao Feng Zhang Xuehao Wang Hai Wang

(99m)Tc-methoxyisobutyl isonitrile (MIBI) is a suitable transport substrate for the multidrug resistance gene product P-glycoprotein (P-gp) and widely used for tumor imaging. Bromocriptine has been shown to inhibit the ATPase activity and the function of P-gp. We hypothesized that bromocriptine could promote the accumulation of MIBI by inhibiting P-gp activities, a feature that can be taken adv...

Journal: :Bioscience reports 1987
A Abu-Jayyab E E el-Denshary A M Ageel M R Dakkak

Short-term and long-term effects of bromocriptine mesylate (10 mg/kg i.p.) on cyclic AMP contents of the liver and some endocrine glands have been investigated in the presence and absence of sulpiride (10 mg/kg i.p.). Results revealed that bromocriptine caused significant elevations in the cyclic AMP contents of the liver and reduction in its adrenocortical content. Bromocriptine effect on the ...

Journal: :Journal of neurochemistry 1984
C A Stratford S K Fisher T Ueda

We studied a protein phosphorylation system that is regulated by the dopamine-mimetic ergot bromocriptine. Bromocriptine was found to inhibit selectively the endogenous phosphorylation of a threonine residue(s) in 50,000- and 60,000-dalton proteins in a synaptosome fraction. The bromocriptine-sensitive phosphorylation is stimulated by calcium and by calmodulin, and occurs predominantly in the b...

Journal: :British medical journal 1983
H D Breidahl D J Topliss J W Pike

A patient with a macroprolactinoma was treated with bromocriptine 15 mg daily. Both the size of the tumour as shown by computed tomography and the serum prolactin concentration decreased over several months but then increased. The dose of bromocriptine was increased to 40 mg daily but tumour growth continued, and the tumour was resected. Production of prolactin by cultured cells was not inhibit...

2011
Ralph A. DeFronzo

B romocriptine is a sympatholytic D2-dopamine agonist that has been approved for the treatment of type 2 diabetes. Based on animal and human studies, timed bromocriptine administration within 2 h of awakening is believed to augment low hypothalamic dopamine levels and inhibit excessive sympathetic tone within the central nervous system (CNS), resulting in a reduction in postmeal plasma glucose ...

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