Oxidative stress plays an important role in the pathogenesis of bronchial asthma. An excess production of reactive oxygen species (ROS) and defective endogenous antioxidant defense mechanisms may be present in asthma. Reduced glutathione (GSH) is one of the most important reducing agents against oxidant free radicals. A reducing agent, L-2-oxothiazolidine-4-carboxylic acid (OTC), a prodrug of c...

BACKGROUND The prevalence of asthma and bronchial hyper-responsiveness is greater in elite athletes than in the general population, and its association with mild airway inflammation has recently been reported. OBJECTIVE To study the relationship between the type of sport practised at the highest levels of competition (on land or in water) and sputum induction cell counts in a group of healthy...

A prospective, randomised, single blind, and controlled trial of a hypnotic technique was undertaken in 39 adults with mild to moderate asthma graded for low and high susceptibility to hypnosis. After a six week course of hypnotherapy 12 patients with a high susceptibility score showed a 74.9% improvement (p less than 0.01) in the degree of bronchial hyper-responsiveness to a standardised metha...

Asthma is traditionally defined as a chronic, multisystem, multicellular disease characterized by bronchial hyper-responsiveness (BHR) and lung inflammation. In this illness is particularly involving the airway epithelium as the place where the inflammation begins, develops and often returns through airway remodelling. In specific way there is also an evolving awareness of the active participat...

Bronchial asthma is a chronic inflammatory disease of the airways, characterized by airway eosinophilia, goblet cell hyperplasia with mucus hyper-secretion, and hyper-responsiveness to inhaled allergens and to non-specific stimuli. Eosinophil accumulation and subsequent activation in bronchial tissues play critical roles in the pathophysiology of bronchial asthma. Many inflammatory mediators at...

KeY wOrds: s ensitization to inhalant allergens is a specific feature of allergic rhinitis. An association between atopy and bronchial hyper-responsiveness was found in patients with allergic rhinitis: namely, exposure to multiple foreign substances increases BHR1 in atopic patients. Recently, interleukin 17A-producing T helper cells have challenged the classic Th1/Th22 paradigm, and have been ...

Bronchial Asthma is a major non-communicable disease affecting both children and adults, nearly 262 million people in India suffer from asthma (WHO). It chronic disorder that affects the airways characterized by bronchial hyper-reactivity reversible airway obstruction. could be correlated as Tamak shwasa Ayurveda considered Pranvaha srotho vikara. The Pathya Aahar Vihara, having Vata Kapha alle...

Background Epidemiological studies in South Africa show increasing prevalence rates of asthma and allergic sensitisation in both urban and rural Black African communities, and narrowing of the urban-rural gradient. There is a paucity of current data on bronchial hyperresponsiveness (BHR) in urban Black African children, associations between asthma and BHR and the relationship between BHR, aller...