We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, characterize αβ, γδ T cell and antibody (Ab) immune responses 2009 pandemic H1N1 virus infection. evaluated kinetic of infection associated response in inbred Babraham pigs identical MHC (Swine Leucocyte Antigen) compared them commercial outbred animals. High level nasal shedding cont...

Bronchopulmonary dysplasia (BPD) is a respiratory distress syndrome caused by chronic lung parenchymal injury, occurring primarily in preterm infants. Therefore, research for early biomarkers for BPD is really important. This study was conducted to evaluate levels of Krebs Von den Lungen-6 (KL-6) and adiponectin in cord blood, neutrophil-gelatinase-associated lipocalin 2 (NGAL2) mRNA gene expre...

A prospective study was performed to detect oxygen saturation (SaO2) during and following fiberoptic bronchoscopy (FOB) in 50 patients. Twenty-five patients (group 1) underwent the procedure without and 25 (group 2) with supplemental oxygen. The SaO2 declined from the baseline value of 96.4% to 92.08% in group 1 and to 94.88% in group 2 after bronchoscopy alone. The decline was also noted when ...

Idiopathic pneumonia syndrome (IPS) refers to diffuse, noninfectious pneumonia that occurs after allogeneic bone marrow transplantation (BMT). We have developed a model of IPS using a well-characterized murine BMT system (B1O.BR -+ CBA) in which lung injury after BMT can be induced by minor histocompatibility (H) antigenic differences between donor and hest. Lung pathology and broncho-alveolar ...

Introduction. Diagnosis of invasive aspergillosis is challenging and the gold standard for definite diagnosis remains histopathological tissue examination. However, invasive procedures such as lung biopsy are often not feasible in critically ill patients. The detection of fungal cell wall components like Aspergillus galactomannan in broncho-alveolar lavage remains a key component of the diagnos...

Two cases of pulmonary alveolar proteinosis were treated with bronchoalveolar lavage (BAL) via a fibreoptic bronchoscope. Additional clinical improvement was seen when trypsin was added to the lavage fluid. Analysis of effluents in the BAL fluid showed marked reduction of protein constituents with clinical improvement after treatment with trypsin in the lavage. BAL with trypsin was well tolerated.

Abstract Purpose To evaluate the association of peripheral blood (PBL) and broncho-alveolar lavage (BAL) biomarkers with inflammatory versus fibrotic high-resolution computed tomography (HRCT) findings in interstitial lung disease (ILD) patients. Methods HRCT 127 consecutive ILD-board patients were semi-quantitatively evaluated: reticulation/honeycombing (RET), traction bronchiectasis (TBR) emp...

1 of 2 DESCRIPTION A 72-year-old woman was admitted to our hospital in August 2011 with a 5-day history of fever. She had been taking predonisolone at 10 mg/day for several years as treatment for autoimmune thrombocytopaenia. On admission, she was febrile with a body temperature of 38.5°C, and peripheral oxygen saturation was 88% in room air. Serum β-D-glucan and galactomannan (GM) testing yiel...