Of 34 symptomatic adult asthmatic patients (23 men) aged 51 +/- 13 years (mean +/- 1 SD) with moderately severe airways obstruction who underwent maximal exercise testing at room temperature (22 degrees C) and humidity (44 percent RH) using a bicycle ergometer, we identified seven male patients aged 56 +/- 9 years in whom forced expired volume in one second (FEV1) increased greater than or equa...

Background: The responsiveness of the endurance shuttle walk to functional changes following bronchodilation has recently been reported. The current literature suggests that the 6 min walking test (6MWT) is less responsive to bronchodilation than the endurance shuttle walk. Aim: To compare bronchodilator-induced changes in exercise performance with the 6MWT and the endurance shuttle walk. Metho...

The onset of bronchoprotection as obtained by various beta2-agonists has not been examined in a comparitive study. In this study, the onset of bronchodilation and protection against exercise-induced bronchoconstriction in asthmatics after inhalation of the long-acting beta2-agonists formoterol and salmeterol and the short-acting beta2-agonist terbutaline were measured. Twenty-five subjects with...

the purpose of this study was to examine the effect of intravenous magnesium sulfate on patients with copd exacerbation requiring hospitalization. in this randomized clinical trial 30 patients with copd exacerbation were studied. patients were randomly assigned to group a (case) who concurrent with standard therapy received 2g magnesium sulfate in normal saline infused in 20 minutes on days one...

A irway smooth-muscle hyperresponsiveness is a characteristic feature of asthma.1 Airway hyperresponsiveness is most commonly identified in the laboratory by the leftward shift of bronchoconstrictor (eg, methacholine) dose-response curves. A reduction in methacholine concentration producing a 20% fall in FEV1 indicates increased ease of development of bronchoconstriction.1–2 Subjects with asthm...