OBJECTIVE To present a wide-ranging review of the literature on broncopulmonary dysplasia, covering new definitions, pathophysiology, prevention, treatment, prognosis and progression. SOURCES OF DATA The most relevant articles published on the subject since it was first described in 1967 were selected from MEDLINE search results. SUMMARY OF THE FINDINGS Bronchopulmonary dysplasia is conside...

background interventricular hemorrhage (ivh) and broncho pulmonary dysplasia(bpd) commonly occur in premature infants and they associate with platelet dysfunction. the aim of this study was to investigate the association of mpv and occurrence of ivh and bpd. materials and methods in this cross sectional study, 3 groups including ivh, bpd and control were compared. all participants were preterm ...

RATIONALE Bronchopulmonary dysplasia is one of the most serious complications observed in premature infants. Thanks to microarray technique, expression of nearly all human genes can be reliably evaluated. OBJECTIVE To compare whole genome expression in the first month of life in groups of infants with and without bronchopulmonary dysplasia. METHODS 111 newborns were included in the study. T...

OBJECTIVE The aim of the present study was to evaluate the prevalence and factors associated with bronchopulmonary dysplasia at a neonatal intensive care unit. METHODS The study was a cross-sectional study that used secondary data from premature infants who were born with less than 32 weeks of gestational age and were admitted to a neonatal intensive care unit. Chi-square, Mann-Whitney and mu...

Respiratory diseases are the most frequent chronic illnesses in babies and children. Although a vigorous innate immune system is critical for maintaining lung health, a balanced response is essential to minimize damaging inflammation. We investigated the functional and clinical impact of human genetic variants in the promoter of NFKBIA, which encodes IκBα, the major negative regulator of NF-κB....

Bronchopulmonary dysplasia is a chronic lung disease seen in infants who have had intensive therapy for respiratory difficulties soon after birth. 1 ,2 ,3 It is characterized by hypoxia, hypercarbia and oxygen dependence, with associated chest roentgenograms showing hyperexpansion, focal hypertranslucency and focal opacification. Severe bronchopulmonary dysplasia has a high mortality.f because ...

UNLABELLED Corticosteroids have been used in bronchopulmonary dysplasia prevention because of their antiinflammatory effects. Among their effects is a decrease in the incidence of bronchopulmonary dysplasia. However, short- and long-term side effects have been detected in preterm newborns. PURPOSE To analyze the effects of corticosteroids on bronchopulmonary dysplasia, length of stay, mortali...

Bronchopulmonary dysplasia (BPD) affects over 15,000 infant births per year in the United States and is one of major causes mortality preterm infants. BPD most common long-term adverse effects from premature birth. Unlike ..