The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Claviceps purpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl(2) (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problem...

the bubble effectiveness in liquid phase cylohexane non-catalytic oxidation process is discussed in this paper. then the bubble effectiveness and a new proposed kinetic model are used in the mathematical model of the industrial reactor for the cyclohexane non-catalytic oxidation process. furthermore, simulation and optimization based on this reactor model are carried out. the results of simulat...

The bubble effectiveness in liquid phase cylohexane non-catalytic oxidation process is discussed in this paper. Then the bubble effectiveness and a new proposed kinetic model are used in the mathematical model of the industrial reactor for the cyclohexane non-catalytic oxidation process. Furthermore, simulation and optimization based on this reactor model are carried out. The results of sim...

In slurry bubble column reactors, catalyst particles may adhere to gas bubbles. Thus, mass transfer limited reactions can be significantly improved either by increasing G-L mass transfer coefficient kL or specific surface area a. The scope of this work is to study the influence of model parameters on coalescence and G-L mass transfer, in order to develop new rules for design and scale-up of slu...