N-Arylated aliphatic and aromatic amines are important substituents in many biologically active compounds. In the last few years, transition-metal-mediated N-aryl bond formation has become a standard procedure for the introduction of amines into aromatic systems. While N-arylation of simple aromatic halides by simple amines works with many of the described methods in high yield, the reactions m...

ABSTRACT The suggestions for writing for publication given in this paper include writing with honesty, thinking clearly, considering the potential audience, sharing the article with friends, revising the article, and sending the article to the appropriate journal. Empathy for the difficulty of writing is given and illustrated with examples from Eric Hcffer, Ernest Hemingway, Art Buchwald, Chaim...

The synthesis of a Pd–NHC cinnamyl-complex supported on calix[8]arene and its use in Buchwald–Hartwig amination is reported. Thanks to the support, products were isolated with low levels residual palladium, some cases below standards.

3,7-Diaminophenothiazine derivatives are readily synthesized via two-fold Buchwald-Hartwig coupling of 10-hexyl 3,7-dibromo-10H-phenothiazine with a series of primary and secondary anilines and amines. All derivatives possess two reversible oxidations at low potentials with remarkable semiquinone formation constants. The electronic structure of this novel class of phenothiazinyl-oligoanilines i...

Buchwald-Hartwig-Migita cross-coupling of 1-thiosugars with α- or β-3-iodo-N-glycosylquinolin-2-ones has been accomplished under mild and operationally simple reaction conditions through the use of a Pd-G3 XantPhos palladacycle precatalyst. This new methodology has been successfully applied to a variety of α- or β-mono-, di-, and poly-thiosugar derivatives to efficiently synthesize a series of ...

A series of new 1-aryl-4-(biarylmethylene)piperazines has been synthesized. These ligands are structurally related to SLV-313, a potential atypical antipsychotic having potent D2 receptor antagonist and 5-HT1A receptor agonist properties. Buchwald-Hartwig coupling reactions of 1-boc-piperazine with appropriate aryl halides and subsequent removal of the boc group rendered arylpiperazines. The re...

J. W. Cleary, R. E. Peale,* D. J. Shelton, G. D. Boreman, C. W. Smith, M. Ishigami, R. Soref, A. Drehman, and W. R. Buchwald Department of Physics, University of Central Florida, Orlando, Florida 32816, USA College of Optics (CREOL), University of Central Florida, Orlando, Florida 32816, USA Sensors Directorate, Air Force Research Laboratory, Hanscom Air Force Base, Massachusetts 01731, USA *Co...