Obsessive-Compulsive Disorder (OCD) is characterized by absurd, recurrent thoughts (obsessions) followed by certain stereotyped actions (compulsions). 5-Hydroxytryptamine (5-HT) abnormalities may be involved in OCD, and further, cause changes in serotonergic transmission that may have direct or indirect effects on the neuronal firing of other neuromodulators affecting thoughts, feelings and beh...

HIGHLIGHTS: Tumor progression and anxiety depression behaviors under evaluation during propranolol use in murine melanoma. Evaluation of through forced swimming behavior tests, elevated plus maze, open field marble-burying test.

According to Gray [The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, New York, 1982], the hippocampus and the septum act in concert to control anxiety. We found that micro-infusion of midazolam into the dorsal hippocampus increased rats' open-arm exploration in the elevated plus-maze. Co-infusion of L-glutamate into the septu...

The present study was undertaken to evaluate the anxiolytic activity of methanolic extract of Sapindus mukorossi Gaertn.(Sapindaceae). The anxiolytic activity was evaluated by Elevated plus maze, Y-maze, Hole-board, Actophotometer, and Marble-burying behavior models. The efficacy of the extract (200 and 400 mg/kg) was compared with the standard anxiolytic drugs Diazepam (2 mg/kg) and Fluoxetine...

Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed the anxiolytic-like effect of a mixture of lauric acid, myristic acid, palmiti...

AIM Withania somnifera root (WSR) extracts are often used in traditionally known Indian systems of medicine for prevention and cure of psychosomatic disorders. The reported experiment was designed to test whether low daily oral doses of such extracts are also effective in suppressing marble burying behavior in stressed mice or not. MATERIALS AND METHODS Groups of mice treated with 10, 20, or ...

INTRODUCTION Clinical and preclinical studies suggest that regulation of nicotinic acetylcholine receptors (nAChR) maybe involved in the etiology of withdrawal symptoms. METHODS We evaluated heteromeric nAChR regulation via [³H]epibatidine binding following cessation of chronic nicotine or varenicline treatment. Animals were concurrently tested in the marble-burying test to evaluate treatment...