The effect of the tyrosine kinase inhibitor genistein on the accumulation of cisplatin (DDP) was investigated in DDP-sensitive and -resistant human 2008 ovarian cardnoma cell lines. DDP accumulation after a 1-h exposure was maximally increased by concurrent 40 piM genistein. The maximal stimulation of accumulation was observed after 2 h of total genistein exposure and was 83 ± 13% (n = 5) highe...

Many mechanisms have been proposed to explain cisplatin resistance, suggesting that this phenomenon is multifactorial. In an attempt to define the chromosome(s) responsible for cisplatin resistance in the human ovarian carcinoma 2008/C13* cell lines, somatic cell hybrids were obtained following fusion of the cisplatin-resistant 2008/C13* cells with an A9 rodent fibroblast cell line. The hybrids...

Low-passage BHK21/C13 cells respond to cytochalasin B (CB) by undergoing limited or controlled nuclear division. These cells respond to CB as normal cells do since nuclear division usually occurs only once. Premature chromosome condensation, a result of mitoses in highly multinucleate cells, occurs in less than 0.5% of the cells. When they are inoculated into weanling hamsters, s. c. tumors app...

Bacterial tRNAs frequently have 4-thiouridine (s(4)U) modification at position 8, which is adjacent to the C13-G22-m(7)G46 base triple in the elbow region of the tRNA tertiary structure. Irradiation with light in the UVA range induces an efficient photocrosslink between s(4)U8 and C13. The temperature dependence of the rate constants for photocrosslinking between the s(4)U8 and C13 has been use...

Glyoxal (CHOCHO) is an atmospheric trace gas produced by the radical-initiated oxidation of hydrocarbons. High resolution measurements of the glyoxal absorption spectrum in the visible wavelength range are needed as reference spectra to calibrate optical spectroscopic measurements of this gas. The UV-vis absorption spectra of C13-disubstituted glyoxal and ambient (C12) glyoxal were collected at...

The effect of the tyrosine kinase inhibitor genistein on the accumulation of cisplatin (DDP) was investigated in DDP-sensitive and -resistant human 2008 ovarian carcinoma cell lines. DDP accumulation after a 1-h exposure was maximally increased by concurrent 40 micrometer genistein. The maximal stimulation of accumulation was observed after 2 h of total genistein exposure and was 83 +/- 13% (n ...

Thirty group covariance data have been produced from ENDF/B VIII.0 MF 33 for H1, H2, He4, Li6, Li7, Be9, B10, B11, C12, C13, N15, O16, the JENDL O16 and F19. Multi-group cross section was by NJOY routine ERRORR. Negative eigenvalues were found only F19, but constraints required condition of sum partial sections being equal to resultant total be incorrect O16. An easy correction is suggested Li6...

1. Starch, containing 7.05 atom per cent C(13) excess has been produced in the mesophyll cells of bean leaves, starting with C(13)O(2) containing 7.26 atom per cent C(13) excess. Approximately 67 per cent of the C(13) taken up by the leaves was determined in the starch fraction. 2. The soluble carbohydrate, containing 6.72 atom per cent C(13) excess, accounts for approximately 23 per cent of th...