In this survey, opsonization activity of sera in 110 patients with meningitis, sepsis and recurrent infection 12 patients after healing and 50 normal adults has been studied. Opsonization activity was measured by an assay depending on electronic particle counting to measure yeast uptake (alternative pathway activator) which was modified in our laboratory. Three classes of immunoglobulins (...

Bioavailability and therapeutic efficacy of soluble Crry, a mouse inhibitor of all complement activation pathways, is significantly enhanced when linked to a fragment of complement receptor 2 (CR2), a receptor that targets C3 activation products. In this study, we characterize alternative pathway-specific inhibitors consisting of a single or dimeric N-terminal region of mouse factor H (fH; shor...

C3–N1′ bond formation of bisindoles has been a great challenge due to the intrinsic reactivity indoles as both C3 and N1-nucleophilic character. Herein, we demonstrate an cross-coupling reaction using N-methoxyindoles N-electrophilic indole reagents in presence Lewis acid. The generated this transformation are latent C3-nucleophile, allowing them be used strategic intermediates sequential C3–N1...