A synthesis of the C29-C51 fragment of spongistatin 1, containing the E and F rings, has been completed. The approach relies on four diastereoselective aldol additions and an asymmetric glycolate alkylation to establish eight of the eleven stereogenic centers. The intact chlorodiene side chain was appended by a Lewis acid catalyzed addition of an allylstannane to an epoxy enol ether.

This paper proposes a deep Reinforcement Learning (RL) based co-design approach for joint-optimization of wireless networked control systems (WNCS) where the can help achieve optimal performance under network uncertainties e.g. delay and variable throughput. Compared to traditional modern methods dynamics system are important predicting system’s future response, model-free adapt many app...

We study structural change in the historical consumption expenditure of United States, Kingdom, Canada, and Australia over more than a century. characterize most general class preferences time-additive setting that admits aggregation saving decision allows us to identify preference parameters from aggregate data. parameterize estimate such intertemporally aggregable (IA) discuss their propertie...

MS36.26.5 Acta Cryst. (2005). A61, C51 Structure-based Vaccine Design of Human Rhinovirus: HIV Chimeras as Candidate AIDS Vaccines Eddy Arnold, Yulia V. Frenkel, Deena A. Oren, Scott A. Hughes, Denise A. Elsasser, Arthur D. Clark Jr., Paola A. Velasco, Jianping Ding, Gail Ferstandig Arnold. Center for Advanced Biotechnology and Medicine, and Department of Chemistry and Chemical Biology, Rutgers...

Abstract Background Little is known about intraprocedural and mid–term results of intravascular lithotripsy (IVL) use in patients with acute MI. Methods In Our retrospective analysis, data from 21 Centers Italy Spain between January 2020 November 2021 were collected. Patients allocated to the AMI–group when IVL was performed during an Primary safety endpoint defined as freedom major adverse car...

The use of GARCH models with stable Paretian innovations in financial modeling has been recently suggested in the literature. This class of processes is attractive because it allows for conditional skewness and leptokurtosis of financial returns without ruling out normality. This contribution illustrates their usefulness in predicting the downside risk of financial assets in the context of mode...

We develop a multivariate generalization of the Markov–switching GARCH model introduced by Haas, Mittnik, and Paolella (2004b) and derive its fourth– moment structure. An application to international stock markets illustrates the relevance of accounting for volatility regimes from both a statistical and economic perspective, including out–of–sample portfolio selection and computation of Value– ...

When countries change most favored nation (MFN) tariffs, partners that trade on MFN terms experience plausibly exogenous tariff changes. Using this variation, we estimate the elasticity at short and long horizons with local projections. We find of tariff-exclusive flows is ?0.76 in run, approximately ?2 run. Our long-run estimates are smaller than typical literature, it takes 7 to10 years to co...

Is credit expansion a sign of desirable financial deepening or the prelude to an inevitable bust? We study this question in modern US data using structural VAR model 10 monthly frequency variables, identified by heteroskedasticity. Negative reduced-form responses output growth are caused endogenous monetary policy response shocks. On average, and remain positively associated. “Financial stress”...