A fundamental property of neuronal networks in Ammon's horn is that each area comprises a single glutamatergic cell population and various types of GABAergic neurons. Here we describe an exception to this rule, in the form of granule cells that reside within the CA3 area and function as glutamatergic nonprincipal cells with distinct properties. CA3 granule cells in normal, healthy rats, similar...

Microporous ceramic material, based on β-tricalcium phosphate β-Ca3(PO4)2 with grain size 2–5 μm, pore smaller than 10 mm, and density 1.22 g/cm3 corresponding to ~40% of the theoretical (3.07 g/cm3) β-Ca3(PO4)2, was obtained from a powder mixture given molar ratio Ca/P = 1.5 after firing at 1100 °C. A homogenized synthetic dicalcium hydrogen phosphates 1 calcium citrate tetrahydrate Ca3(C6H5O7...

We asked whether the structural heterogeneity of the hippocampal CA3-CA2 axis is reflected in how space is mapped onto place cells in CA3-CA2. Place fields were smaller and sharper in proximal CA3 than in distal CA3 and CA2. The proximodistal shift was accompanied by a progressive loss in the ability of place cells to distinguish configurations of the same spatial environment, as well as a redu...

The CA1-projecting axons of CA3 pyramidal cells, called Schaffer collaterals, constitute one of the major information flow routes in the hippocampal formation. Recent anatomical studies have revealed the non-random structural connectivity between CA3 and CA1, but little is known regarding the functional connectivity (i.e. how CA3 network activity is functionally transmitted downstream to the CA...

To better understand encoding and decoding of stimulus information in two specific hippocampal sub-regions, we isolated and co-cultured rat primary dentate gyrus (DG) and CA3 neurons within a two-chamber device with axonal connectivity via micro-tunnels. We tested the hypothesis that, in these engineered networks, decoding performance of stimulus site information would be more accurate when sti...

Dentate granule cells exhibit exceptionally low levels of activity and rarely elicit action potentials in targeted CA3 pyramidal cells. It is thus unclear how such weak input from the granule cells sustains adequate levels of synaptic plasticity in the targeted CA3 network. We report that subthreshold potentials evoked by mossy fibers are sufficient to induce synaptic plasticity between CA3 pyr...

Degeneration of CA3-pyramidal neurons in hippocampus after intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, results in hyperexcitability within both dentate gyrus and the CA1 subfield. It also leads to persistent reductions in hippocampal glutamate decarboxylase (GAD) interneuron numbers without diminution in Nissl-stained interneuron numbers, indicati...

objective it has previously been shown that prenatal maternal administration of boswellia serrata gum resin (frankincense) improved learning and memory performance associated with an increase in the size of neuronal bodies in ca3 (cornu ammonis) of hippocampus. continuing the previous work, a morphometric study was designed on ca3 field to examine precisely the effect of prenatal administration...

in the current study, we assessed the role of transient receptor potential (trp) channels on avoidance memory and anxiety states in ca3 area of the hippocampus. we explored the anxiety and avoidance memory states using test-retest protocol in the elevated plus maze to understand whether trp channels can affect the above mentioned states in ca3 area. to investigate the consolidation phase of mem...

background and objectives: hippocampal volume reduction has been reported in diabetes mellitus type 1. it is believed that hyperglycemia and oxidative stress mediate neuropathological changes in hippocampal neurons. in this study we aimed to study the effect of insulin and an antioxidant like ascorbic acid on preventing volume changes of dentate gyrus and ca3 region of hippocampus. materials an...