Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of the CYP4A11 and CYP4F2 genes are associated with the risk of CAD in Russian population. DNA samples from 1323 unrelated subjects (637 angiographically confirmed CAD patients and 686 age...

Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips have enabled us to perform genome-wide association studies (GWAS) on a large number of subjects w...

BACKGROUND In patients with acute coronary syndrome (ACS), elevated levels of soluble CD40 ligand (sCD40L) are associated with increased risk of cardiovascular events. We evaluated sCD40L levels and future cardiovascular events in patients not experiencing ACS. METHODS Serum sCD40L levels were measured in 909 patients undergoing angiography. A three-way matching scheme (age, gender and cathet...

Oxidation of low density lipoproteins (LDL) obviously plays an important role in the pathogenesis of atherosclerosis. The purpose of the study was to determine whether antibodies against oxidized LDL are associated with coronary artery disease (CAD). We determined the serum levels of antibodies against copper-oxidized LDL by enzyme-linked immunosorbent assay in 58 patients with angiographically...

The pathogenesis of a cervical artery dissection (CAD) remains unknown in most cases.1,2 Dissections are usually classified as either traumatic or spontaneous.3 However, mechanical trauma did not appear to be an important and frequent cause for the development of CAD, neither in clinical nor in histopathological studies. Chiropractic maneuver, for instance, was repeatedly discussed as a risk fa...

Coronary artery disease (CAD) is defined as myocardial damage developing a result of its organic and functional changes, leading to impaired blood flow through the coronary arteries. An important pathogenetic component CAD atherosclerosis. Currently, key aspects molecular relationship between inflammation atherosclerosis are being actively studied, immunometabolic theory discussed, along with a...

BACKGROUND Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). Here, we investigated whether serum levels of CTRP 3 are associated with the prevalence and t...

BACKGROUND Tissue factor pathway inhibitor (TFPI) is the main physiological inhibitor of TF-induced blood coagulation process, and may play essential roles in the pathogenesis of major adverse cardiac events. This study was designed to determine whether the variation of TFPI was related with coronary artery disease (CAD) in the Han Chinese populations. METHODS A total of 1271 patients with co...

Pathogenesis of coronary artery disease (CAD) is multi-factorial and many risk factors are associated with development of CAD. LDL-C has been an important target for therapeutic interventions and has been extensively studied. But, various studies have indicated that estimation of LDL-C is not enough to assess the risk. Moreover, LDL particles vary in their content, density and size which have d...

Coronary artery disease (CAD) is one of the prominent causes of demise in the world. Despite large number of study reports on pathogenesis of atherosclerosis and the development of ischemic heart disease there are numerous questions that are unrequited. About 70% of the risk factors associated with the CAD events are addressed by the classic factors while the other 30% of the CAD events do not ...