introduction: leukoplakia is the most common precancerous lesion of the oral mucosa and may range microscopically form benign hyperkeratosis to invasive squamous cell carcinoma. p53 is a tumor suppressor protein; whereas, proliferative cell nuclear antigen (pcna) is a proliferative marker. the aim of this study was to evaluate the immunohistochemical expressions of p53 and pcna in oral leukopla...

schimke immuno-osseous dysplasia is a rare autosomal recessive multisystem disorder characterized by steroid-resistant nephrotic syndrome, immunodeficiency, and spondyloepiphy-seal dysplasia. mutations in swi/snf2 related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (smarcal1) gene are responsible for the disease. the present report describes, for the first tim...

it is sometimes difficult to recognize a jaw lesion as osteosarcoma, ossifying fibroma or ‎fibrous dysplasia in routine hematoxylin and ‎eosin staining and a more accurate technique is needed to differentiate these ‎lesions. ‎many studies have shown the potential usefulness of silver-stained nucleolar organizer region (agnor) parameters for the diagnosis of various neoplasms. this study was car...

Camptomelic dwarfism or dysplas1a is a rare syndrome in which· short stature is associated with angulation and bowing of the lower limb Long bones, hypoplasia of the facial bones and scapula and various other skeletal and respiratory and nervous system. A 9 day old girl with this syndrome was admitted in our peiatric Department, Loghman Hospital medical center because of Dwarfism and hypotonia....

in this case report we will describe a rare association between anhyrotic ectodermal dysplasia (aed) and immunodeficiency and autoimmunity [in our case: idiopathic thrombocytopenic purpura (itp) and crohn disease]. aed is a rare congenital disorder characterized by sparse hair, abnormal teeth and anhidrosis due to lack of eccrine glands. the survey of 87 cases with (aed) revealed only one irrit...

Abstract Background A metaplasia-dysplasia–carcinoma sequence is the most plausible carcinogenic pathway for gallbladder cancer. Although incidence of carcinoma increasing, little known about its precancerous lesions. The aim this study was to determine temporal changes in prevalence low-grade dysplasia (LGD), high-grade (HGD) and adenocarcinoma associated risk factors. Methods We retrospective...

Fibrous dysplasia (FD) is an osseous growth dis-order, producing immature bone and characte-rized by the replacement of normal bone with fibro-osseous connective tissue. It is a bone dys-plasia that has the potential to cause significant cosmetic and functional disturbances, particularly in the craniofacial skeleton. Cra-niofacial fibrous dysplasia is one of the three types of polyostotic fibro...

background & aim: regional odonto dysplasia (rod) is an unusual nonhereditary of teeth with significantly clinical and radiographic features. affected teeth usually remain unerupted or semi-erupted with a discolaration and irregular shape. radiographically these teeth have a large pulp chamber and thin layer of enamel and dentin with similar density. this article is introducing a female patient...

colorectal cancer is the second leading cause of cancer death worldwide. through risk assessment of malignancy in polyps, screening programs can achieve the best results. this study aimed to determine the association between the grade of dysplasia and the location of colorectal polyps. 240 colorectal adenomatous polyps which were referred to department of pathology at rasoul-e-akram hospital be...

intracranial lipomas are congenital malformations. these uncommon lesions have an incidence of 0.1 to 1.7% of all intracranial tumors. most cases are located at midline and 5% are along the sylvian fissures. if symptomatic, seizures are the most common symptom. these tumors are slow growing and have favorable outcome. we report a case of a 25-year-old man whose ct and mri revealed a lesion in r...