conclusions since telomerase is expressed in 90% of cancer cells, its inhibition can be considered as a goal of cancer treatment. results about 90% of cancers need a high level of this enzyme to continue cell multiplication. since this enzyme set is absent in normal cells, or present at a very low level, use of telomerase inhibitors cannot have significant effects on normal cells. evidence acqu...

A 76-year-old woman presented with hypotension noted to be atrial fibrillation. Her medical history was significant for diabetes mellitus, hypertension, morbid obesity, end-stage renal disease, and gastroesophageal reflux disease with known large hiatal hernia. After presentation, she developed nausea, vomiting, and vague epigastric pain. Chest computed tomography (CT) demonstrated an intrathor...

Abstract BACKGROUND Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer. In cases invisible or non-endoscopically resectable dysplasia found colonoscopy, total proctocolectomy ileal pouch anal anastomosis can be offered good long-term oncological outcomes and survival, however, little is known regarding cancer-related when incidentally after surgery. We hyp...

background only a few studies in western countrieshave investigated the association between gastroesophageal reflux disease(gerd) and mortality at the general population level and they have shown mixedresults. this study investigated the association between gerd symptoms andoverall and cause-specific mortality in a large prospective population-based studyin golestan province, iran. methods base...

An 85-year-old female was diagnosed with cerebellar hemorrhage based on computed tomography (Figure A). She underwent a craniotomy to remove the hematoma. It has been 2 months since she started rehabilitation after but still experiences repeated vomiting. Therefore, gastrointestinal transit disorders were considered differential diagnosis. esophagogastroduodenoscopy performed for detailed exami...

background: one of the most important environmental risk factors for kidney cancer is occupational exposure to chemical carcinogens. since the isfahan province is one of the major industrial centers in iran and various chemical industries operating in the province, this study was conducted to determine the association of kidney cancer and occupation. methods: this case-control study was conduct...

Abstract Background Survival of patients with cardiovascular disease and cancers has increased due to improved treatments. However, the prognosis acute coronary syndrome (ACS) in cancer is widely unknown, challenging clinical decision-making. Purpose To investigate selected treatment strategy for most prevalent (breast, gastrointestinal lung cancer), according status, following first-time ACS. ...

Background VT1021 is a first-in-class therapeutic agent in Phase I clinical studies solid tumors. In vivo preclinical demonstrated that inhibited tumor growth via stimulation of p53 and Thrombospondin-1 (Tsp-1) MDSCs. Moreover, induction Tsp-1 reprogrammed the microenvironment induced apoptosis cells its cell surface receptors CD36 CD47. Here we report on utility as pharmacodynamic biomarker co...