Optimizing drug combination treatment has been an area of interest for a while, from the beginning with emergence POMP regime. The ability to improve combinations cancer comes up against possibility several limitations, such as lack specificity drugs, generating systemic toxic effects, and also great tumor cells resistant drugs. development nanooncology offers advances in new alternatives cance...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

Today, nanoscience has grown and developed in various medical and therapeutic areas, including cancer treatment. On the other hand, cancer and its types have been rumored and inclusive and many people suffer from this fatal and deadly disease. Currently, existing therapeutic method, including chemotherapy, radiotherapy, and etc., along with the therapeutic effect, cause complications that are u...

conclusions vpa and cbz treatments caused a decrease in β-catenin and vegf levels in sw480 colon cancer cell lines. these results suggest that cbz can be considered a potential antitumor drug with potencies different from vpa. methods in the present experimental study, implemented during 2014 - 2015 in iran, after incubation of cells into 96-well plates with 5,500 cells/well, the tested drugs w...

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

objective: breast cancer is one of the leading causes of death in women worldwide. conventional treatments use cytotoxic drugs which have high numbers of side effects. currently pharmacologists are searching for novel drugs with fewer side effects and maximum efficiency as breast cancer treatment. the aim of the current study is to clarify the cytotoxicity effect of the recombinant outer membra...

hormone-independent prostate cancer cell lines are resistant to antineoplastic drugs, this study sought to determine the usefulness of lithium chloride as an inhibitor of glycogen synthase kinase-3β to increase the cytotoxic effect of doxorubicin, etoposide or vinblastine antineoplastic drugs on du145 cells. combination effect was assessed by using low and ic50 doses of drugs + lithium chloride...

cancer patient receive various cytotoxic drugs in association with antiemetic drugs such as 5ht3 receptor antagonists as their chemotherapy regimen. 5ht3 receptor antagonists have been reported to produce changes in ecg parameter. there are only a few studies about cardiovascular events of these drugs in patient receiving potentially cardiotoxic chemotherapies. the subject of this study is to e...