Introduction: Prostate cancer (PCa) is the most prevalent malignant tumor in the male population worldwide and it is the second leading cause of cancer-related death in males. PCa is almost incurable due to the resistance of PCa to conventional treatments. Cancer stem cells (CSCs) theory suggests that a small subpopulation of cancer cells is responsible for tumor development, ...

Cancer stem cells (CSCs) are now well-established as key players in tumor initiation, progression, and therapy resistance [...]

Cancer stem cells (CSCs) have been identified in many types of cancer since their discovery leukemia the 1990s. CSCs self-renewal and differentiation capacity, are thought to be a key driver for establishment growth tumours. Several intracellular signalling pathways reported play significant role regulation biological activities CSCs. Thus, researchers considered compelling therapeutic target c...

The concept of cancer stem cells (CSCs) is the hot topic of the day and everyone is talking about them. Patients with metastases now know that their condition is due to recurrent CSCs with increased resistance to chemotherapeutics (rCSCs). However, there is confusion and controversy about the origin and development of CSCs in the scientific community. Where do CSCs come from and how do they dev...

cancer stem cells (csc) are the tumor-associated cells existed within tumors or hematological cancers which share characteristics similar to normal stem cells. the common characteristics of a normal stem cell and a csc are their differentiation capacity and self-renewal in tumors. the expression pattern of csc markers differs depending on the type and location of cancers. cd molecules are proba...

Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...

Cancer stem cells (CSCs) represent the most aggressive subpopulation present in tumor bulk retaining invasive capabilities, metastatic potential and high expression levels of drug efflux pumps responsible for therapy resistance. is still an incurable disease due to inefficacy standard regimens that spare this subpopulation. Selective targeting CSCs unmet need cancer research field. Aberrant epi...

The presence of small subpopulations cells within tumor are known as cancer stem (CSCs). These have been the reason for metastasis, resistance with chemotherapy or radiotherapy, and relapse in several types cancers. CSCs underwent to epithelial–mesenchymal transition (EMT) resulted development aggressive tumors. potential modulate numerous signaling pathways including Wnt, Hh, Notch, therefore ...