supernumerary teeth are defined as the teeth developed in excess of the number found in a normal dentition. supernumerary canine is an extremely rare finding particularly in the mandible. this case report presents a 25-year-old female patient with the unique feature of bilateral mandibular supplemental supernumerary canines. the patient was non-syndromic without any other supernumerary teeth.

PURPOSE A three-dimensional finite element analysis based canine heart model is introduced that would enable the assessment of cardiac function. METHODS The three-dimensional canine heart model is based on the cardiac deformation and motion model obtained from the Cardiac Mechanics Research Group at UCSD. The canine heart model is incorporated into ultrasound simulation programs previously de...

Interleukin 13 receptor alpha 2 (IL-13RA2) is over-expressed in a vast majority of human patients with high-grade astrocytomas like glioblastoma. Spontaneous astrocytomas in dogs resemble human disease and have been proposed as translational model system for investigation of novel therapeutic strategies for brain tumors. We have generated reagents for both detection and therapeutic targeting of...

BACKGROUND The pathological condition of canine prostate cancer resembles that of human androgen-independent prostate cancer. Both canine and human androgen receptor (AR) signalling are inhibited by overexpression of the dimerized co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA), which is considered to cause the development of androgen-independency. Reduced...

Canine lymphoma is a common spontaneous tumor with many similarities to human lymphoma, and thus has potential to be an important animal model of lymphomagenesis. This study determined that microRNA (miRNA) expression in canine tumors can be assessed using a commercially available human cancer miRNA qPCR array. miRNA expression in six different canine lymphoid cell lines and in naturally occurr...

Canine prostate is widely used as animal model in the preclinical evaluation of emerging therapeutic interventions. Spontaneous benign prostatic hyperplasia (BPH) is common in adult intact male dogs with two distinct pathological types: glandular and complex form of prostatic hyperplasia. The complex form of prostatic hyperplasia, usually occurring in older dogs, represents an ideal model becau...

background: to provide a point of reference to study the epidemiology and clin-ical expression of canine babesiosis in china. methods: a total of 30 dogs infected with canine babesiosis were evaluated by mean of clinical history, physical examination, hematological, restriction fragment length polymorphism of pcr products (pcr-rflp) and sequencing analysis. result: the most prevalent clinical a...

Abstract Introduction: Maxillary canines commonly have an ectopic eruption. This study aimed to assess the factors related to the ectopic maxillary permanent canines. Materials and Methods:This was a descriptive cross-sectional study of 1357 panoramic radiographs from patients 8 to 13 years old. The radiography was excluded if the patient had any developmental disease or if the panoramic im...