introduction: β-carbolines are shown to have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including tnf-α and pge2. in previous studies purkinje cell deterioration have been proposed the dominant pathogenesis of harmaline toxicity. win55, 212-2 is a non-selective cannabinoid cb1 and cb2 receptor agonist. combination of win55, 212-2 and am 251(cb1-select...

Introduction: β-carbolines are shown to have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including TNF-α and PGE2. In previous studies Purkinje cell deterioration have been proposed the dominant pathogenesis of harmaline toxicity. WIN55, 212-2 is a non-selective cannabinoid CB1 and CB2 receptor agonist. Combination of WIN55, 212-2 ...

Marijuana is the most commonly abused drug in the United States.1 It mainly acts on cannabinoid receptors. There are two types of cannabinoid receptors in humans: cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2). CB1 receptor activation is pro-atherogenic, and CB2 receptor activation is largely anti-atherogenic. Marijuana use is also implicated as a trigger for myocardial...

lithium (li), a glycogen synthase kinase-3β (gsk-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. recent studies indicate the involvement of upstream extracellular signal kinase1/2 (erk1/2)and downstream gsk-3β pathways in the development of cannabinoid-induced dependence. thisis mediated through cannab...

AM 251 ALX-270-239-M001 1 mg ALX-270-239-M005 5 mg Structurally related to the cannabinoid receptor (CB) antagonist SR 141716A. Binds with high affinity to cannabinoid receptor CB1 (Ki=7.49nM; 306-fold selective over CB2 receptors). LIT: Binding of the non-classical cannabinoid CP 55, 940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors: S.J. Gatley, et al.; Life Sci. 61, PL ...

Cannabinoids, the active constituents of marijuana, are known to impair learning and memory. Receptors for cannabinoids are highly expressed in the hippocampus, a brain region that is believed to play an important role in certain forms of learning and memory. To investigate the possible contribution of cannabinoid receptor-mediated deficits in hippocampal function to the learning and memory imp...

BACKGROUND The endogenous cannabinoid system is involved in the control of pain. However, little is known as to the integrity of the cannabinoid system in human pain syndromes. Here we investigate the expression of the cannabinoid receptor 1 (CB₁) in human Achilles tendons from healthy volunteers and from patients with Achilles tendinosis. METHODOLOGY Cannabinoid CB₁ receptor immunoreactivity...

......................................................................................................................................... iii Acknowledgements ......................................................................................................................... v List of Figures and Tables...........................................................................................