WHAT IS KNOWN AND OBJECTIVE The pharmacokinetics (PK) and pharmacodynamics (PD) of levofloxacin were investigated following administration of levofloxacin injection in healthy Chinese volunteers for optimizing dosing regimen. METHODS The PK study included single-dose (750 mg/150 mL) and multiple-dose (750 mg/150 mL once daily for 7 days) phases. The concentration of levofloxacin in blood and ...

OBJECTIVES Evaluation of the effectiveness, safety and tolerability of gatifloxacin in the treatment of outpatients with community-acquired pneumonia (CAP). STUDY DESIGN A prospective, multicenter, non-comparative clinical study carried out in Brazil. Voluntary, unpaid physician participation contributed to an unbiased study design. PATIENTS Adult outpatients with clinical diagnosis of CAP....

OBJECTIVE To evaluate adherence to the South African guidelines for the management of community-acquired pneumonia (CAP) and to determine whether adherence reduced length of hospital stay and mortality in patients with severe CAP. SETTING King Edward VIII Hospital, Durban. METHODS Four hundred and thirty patients with CAP were recruited between June 2000 and October 2001. Severity assessmen...

BACKGROUND Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia. AIMS To develop novel regimen fo...

BACKGROUND Changing etiologic patterns and the growing problem of antimicrobial resistance, particularly an increase in macrolide-resistant pneumococcal bacteremia, are causing physicians to adopt new approaches to the treatment of community-acquired pneumonia (CAP). OBJECTIVE The relative efficacy and tolerability of levofloxacin monotherapy and azithromycin and ceftriaxone combination thera...

Background . At the height of novel coronavirus infection, risk fungal coinfection increases due to a decrease in immune status patients and massive antibacterial therapy, which leads complication course underlying disease an unfavorable outcome. Therefore, it is necessary not only identify all associates that cause infectious process, but also determine their sensitivity antifungal drugs order...

Community-acquired pneumonia (CAP) is a common cause of hospitalization and mortality worldwide. A timely start an adequate choice the initial antibiotic therapy (ABT) regimen are key strategy for optimizing prognosis in severe CAP. The aim was to study practice using systemic antimicrobial drugs (AMDs) adults with CAP multidisciplinary hospitals Russian Federation, as well assess compliance AB...

introduction: acute leukemia covers a broad spectrum of hematological clonal diseases originating from the malignant transformation of stem cells. current chemotherapeutic methods result in an incomplete response to primary regimens in 30-40% of cases. methods: 20 patients who had been diagnosed with acute leukemia and who had displayed defined criteria in order to enter our study, were assesse...