The constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) are master regulators of drug metabolism and gluconeogenesis, respectively. In supporting the cross talk between drug metabolism and energy metabolism, activation of CAR has been shown to suppress hepatic gluconeogenesis and ameliorate hyperglycemia in vivo, but the underlying ...

This paper presents the complete description of a non-iterative algorithm for the distributed component based simulation of the dynamics of multibodies. The simulation of well-partitioned systems has complexity O(N), where N is the total number of bodies. The algorithm was implemented in the Virtual Systems Developer (VSD) software. In contrast to other tools, this one maintains the object-orie...

Processing bodies (P bodies) are conserved mRNA-protein (mRNP) granules that are thought to be cytoplasmic centers for mRNA repression and degradation. However, their specific functions in vivo remain poorly understood. We find that repressed maternal mRNAs and their regulators localize to P body-like mRNP granules in the Caenorhabditis elegans germ line. Surprisingly, several distinct types of...

Ice bodies in the semi-arid mountainous regions of Chile are of vital importance for the local population. As variations of their extent are often associated with climate change, this study focuses on the glaciers and glacierets situated in the Commune Alto del Car‐ men and local and regional climate. We combine statistically Landsat satellite imagery, historical and ongoing weather data. The p...

The car aerodynamicist developing passenger cars is primarily interested in reducing aerodynamic drag. Considerably less attention paid to the lift characteristics except case of high-performance cars. Lift, however, can have an effect on both performance and stability, even at moderate speeds. In this paper, basic shape features which affect distribution, as determined from axle loads, are exa...

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Foreign bodies in the paranasal sinuses are rare and mostly related to maxillo-facial trauma. We treated a 47-year-old man with a late complication arising from a foreign body in the nasoethmoid sinus present for 16 years after a road traffic accident. Patients presenting with maxillo-facial injuries, especially those with lacerations due to glass or car wind-screen trauma should have thorough ...