نتایج جستجو برای: carbapenems
تعداد نتایج: 3646 فیلتر نتایج به سال:
Strategy of elimination antibiotcoresistance to carbapenems – actual modern problem
We examined the effect of the addition of ertapenem to our hospital formulary on the resistance of nosocomial Pseudomonas aeruginosa to group 2 carbapenems (imipenem, meropenem, and doripenem). This was a retrospective, observational study conducted between 1 January 2000 and 31 January 2009 at a large, tertiary-care hospital. Autoregressive integrated moving average (ARIMA) regression models w...
The comparative effectiveness and safety of carbapenems with other beta-lactams and fluoroquinolones for the empirical treatment of patients with hospital-acquired pneumonia remains controversial. In the present study, a meta-analysis of 12 relevant randomised controlled trials was performed. Overall, carbapenems were associated with lower mortality than fluoroquinolones or beta-lactams, alone ...
OBJECTIVES This systematic review and meta-analysis compared effects of different antibiotics on mortality in patients with bloodstream infections caused by Enterobacteriaceae with chromosomal AmpC β-lactamase. METHODS Databases were systematically searched for studies reporting mortality in patients with bloodstream infections caused by AmpC producers treated with carbapenems, broad-spectrum...
Carbapenems constitute a class of broad-spectrum antibiotics for the treatment of documented multidrug-resistant organisms and for use as empiric therapy in severe, life-threatening conditions,1,2 Hospital-acquired infections due to organisms such as Clostridium difficile and multidrug-resistant Pseudomonas aeruginosa are responsible for significant morbidity and mortality in the institutional ...
A new type of 5,6-cis-carbapenems (racemic) having a sulfonyl group in the C-6 side-chain were synthesized by employing the synthetic methodology reported in our previous papers, and an alternative stereocontrolled synthesis of these 5,6-cis-carbapenems was achieved starting from 8oxo-7-azabicyclo[4.2.0]oct-3-ene (14) via an intramolecular aldol condensation as the key step. Chiral 5,6-cis-carb...
Resistance to carbapenems is emerging, and it is a great problem to therapeutics. Seven multidrug-resistant (MDR) of Pseudomonas aeruginosa strains were isolated from urine and bronchial specimens. All isolates showed resistance to imipenem and meropenem (MIC; > or =16 mg/L). The resistance to carbapenems in two of seven strains was associated with the production of a metallo-beta-lactamases. P...
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