conclusions se supplementation can increase plasma se concentration and rbc gsh-pxs activity in patients with different stages of ckd. background plasma selenium (se) concentration and glutathione peroxidase (gsh-pxs) enzyme activity of the patients with chronic kidney disease (ckd) are usually lower than healthy individuals; however, the effect of se supplementation on the gsh-pxs activity in ...

BACKGROUND Subjects consuming protein-restricted diets, such as patients with phenylketonuria (PKU) or milder hyperphenylalaninemias (HPAs) are at risk of selenium deficiency. Selenium is a cofactor of the antioxidant enzyme glutathione peroxidase and of the thyroid hormone converting enzyme thyroxine deiodinase. OBJECTIVE Our goal was to investigate the effects of low plasma selenium on anti...

BACKGROUND Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins. Although there is no evidence of selenium deficiency in the United States, people in many other areas of the world are selenium deficient, with the consequence that they are unable to express their selenoproteins fully. OBJE...

Two enzymatic mechanisms have been proposed for the metabolism of hydroperoxy-phospholipids: i) the combined action of phospholipase A2 and glutathione peroxidase, and/or ii) direct enzymatic reduction. The latter reaction may be catalyzed by selenium-dependent phospholipid hydroperoxide glutathione peroxidase and/or by glutathione S-transferase alpha. To study the pathway of this reaction, we ...

Submit Manuscript | http://medcraveonline.com J Aquac Mar Biol 2015, 2(4): 00035 Abbreviations: SOD: Superoxide Dismutase; CAT: Catalase; TAC: Total Antioxidant Capacity; MDA: Malondialdehyde; ROO: Primarily Peroxyl Radicals; GPX: Glutathione Peroxidase; ROS: Reactive Oxygen Species; GST: Glutathione-S-Transferase; GR: Glutathione Reductase; PPT: Parts Per Trillion; Ppm: Parts Per Million; RPM:...

The endogenous defenses of the mouse heart against reactive oxygen metabolites were investigated. The activities of three enzymes capable of detoxifying activated oxygen were determined in both the heart and liver; cardiac muscle contains 150 times less catalase and nearly four times less superoxide dismutase than liver. Glutathione peroxidase activities were, however, similar to the two tissue...

Toshio Kaneko, MD, Third Department of Internal Medicine, Yamaguchi University School of Medicine, Koguchi, Ube Yamaguchi 755 (Japan) Oxidative damage of red cell membrane is known to be accelerated in sickle cell disease. However, the exact mechanism of this acceleration is unclear. We have read with interest the recent article entitled ‘Selenium and Glutathione Peroxidase Levels in Sickle Cel...

conclusions plasma se and gpx levels were lower in type two diabetic patients with macroalbuminuria and related to the stage of diabetic nephropathy. results plasma se and gpx concentrations were significantly lower in diabetic patients with macroalbuminuria than other study groups (p < 0.001). albuminuria (alb/cr in random urine sample) had a negative correlation with plasma se (r = -0.40, p =...

Two concepts are often currently applied to selenium in adult men in the United States: • Intake is generally enough to maximize blood glutathione peroxidase activities. • In such men, selenium supplementation does not reduce risk of prostate cancer. In contrast to these concepts, 30 healthy middle-aged men were studied to test the following hypothesis: 6-week supplementation of 200 μg of selen...

Harapin I . , M. Bauer , L. Bedrica, D. Potoãnjak: Correlation Between Glutathione Peroxidase Activity and The Quantity of Selenium in The Whole Blood of Beef Calves. Acta Vet. Brno 2000, 69: 87–92. The aim of the study was to establish concentration of selenium and the pertinent activity of glutathione peroxidase (GSH-Px ) in whole blood that could be used as reference values in future researc...