Ionizing radiations (4), carcinogenic hydrocar bons (12), and estrogenic hormones (8) are leuke mogenic for mice of specific genetic constitutions (8). Synergistic and additive effects of x-rays and methylcholanthrene have been demonstrated (1, 13). A preliminary paper has been published on the synergistic action of x-rays and an estrogenic hormone (9). In the present report genetic requirement...

Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components containing more than 2,200 entries was generated. Emission levels in mainstream smoke have been ...

The experimental carcinogenesis results in six compounds related to vinyl chloride are reported. Vinylidene chloride, given by inhalation, was carcinogenic in male CD-1 mice, male CD rats, Sprague-Dawley rats and male Swiss mice. Trichloroethylene, given by gavage and inhalation, was carcinogenic in the B6C3F1 mice. When given by gavage, perchloroethylene was carcinogenic in the B6C3F1 mice, an...

Fragments of embryonic kidney were explanted in organ culture. The embryos were obtained from mice that, during the last third of their pregnancies, received the polycyclic hydrocarbons 7,12-dimethylbenz(a)anthracene (carcinogenic), benz(a)pyrene (carcinogenic), and their analogs anthracene (noncarcinogenic) and pyrene (noncarcinogenic); the carcinogenic cyclic amines, o-tolidine and 3,3'-dichl...