OBJECTIVES To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. METHODS The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). RESULTS The rates of expressi...

undifferentiated nasopharyngeal corcinoma is frequently misdiagnosed as large cell malignant lymphoma. the aim of this study is to evaluate the diagnostic role of immunohistochemistry and electron microscopy in this tumor. 81 cases of nasopharyngeal carcinoma were studied. patients ranged from 9-90 years in age (mean: 48.5 years). the age incidence curve was bimodal with two peaks in 2-3 and 5-...

abstract   background: nasopharyngeal carcinoma (npc) is a nonlymphomatous squamous cell carcinoma (scc) that occurs in the epithelial lining of the nasopharynx. viral, geographic, and ethnic factors are responsible for its multifactorial futures. previous studies have showed the role of epstein-barr virus (ebv) in the pathogenesis of npc but no study has been conducted on the iranian populatio...

Objective: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma carcinoma cases, to relate their with the available clinicopathological data.Methods: The retrospective study was conducted at Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 October 2020, comprised formalin-fixed paraffin-embedded specimens related cas...

Background/Aim: Prognosis plays a vital role in head and neck squamous cell carcinoma (HNSCC) patient management decision-making. This study aimed to identify the of BP180 as prognostic factor HNSCC. Patients Methods: Protein expression bullous pemphigoid antigen II (BP180) was verified by immunohistochemistry (IHC) tissue microarray 202 cases. Results: IHC analysis revealed that protein among ...

A quantitative immunoassay procedure has been constructed to evaluate levels of ductal carcinoma antigen recognized by murine McAb F36/22. Using this method, 3% of 64 apparently healthy individuals and 13% of 40 patients with benign breast disease expressed serum antigen levels above 70 units/ml. Greater than 50% of 116 patients with clinical evidence of breast cancer demonstrated circulating d...

Despite intensive treatment, pancreatic adenocarcinoma still has the worst prognosis among all malignancies. Using clinically relevant models, we demonstrated the therapeutic efficacy of adoptively transferred T cells engineered with a carcinoembryonic antigen (CEA)- and ERBB2-specific chimeric antigen receptor against pancreatic carcinoma. Targeting CD24, a putative cancer stem cell antigen ex...

Objective To study the structural relationship between annexin A4 and the Lewis y antigen and compare their expression and significance in ovarian clear cell carcinoma, and to explore how annexin A4 fucose glycosylation effects the interaction between annexin A4 and NF-kB p50, and how it promotes tumour progression of ovarian clear cell carcinoma. Methods Structural relationships between anne...

We determined estrogen receptor protein and carcinoembryonic antigen in cytosols prepared from 189 human breast carcinoma tissues, 85 benign or normal breast biopsies, and 101 tissue specimens metastatic from breast carcinoma. Carcinoembryonic antigen was observed in 70% of the primary carcinomatous tissues, 15% of the benign or normal specimens, and 51% of the metastases. Ninety-six of the 189...