A new approach for investigating the mechanisms and evolution of cardiac muscle cell injury was presented by applying fine structural extracellular protein tracers in the catecholamine-induced cardiac muscle cell injury model. The results with these diffusion tracers indicated striking functional changes at the level of coronary microcirculation followed by early permeability alteration of card...

BACKGROUND Septic acute liver and intestinal failure is associated with a high mortality. We therefore investigated the influence of volume resuscitation with different crystalloid or colloid solutions on liver and intestine injury and microcirculation in septic rodents. METHODS Sepsis was induced by cecal ligation and puncture (CLP) in 77 male rats. Animals were treated with different crysta...

The effect of small hematocrit (Hct) increases on cardiac index (cardiac output / body weight) and oxygen release to the microcirculation was investigated in the awake hamster window chamber model, by means of exchange transfusions of homologous packed red blood cells. Increasing Hct between 8-13% from baseline increased cardiac index by 5 31% from baseline (P < 0.05) and significantly lowered ...

The effect of small hematocrit (Hct) increases on cardiac index (cardiac output/body wt) and oxygen release to the microcirculation was investigated in the awake hamster window chamber model by means of exchange transfusions of homologous packed red blood cells. Increasing Hct between 8 and 13% from baseline increased cardiac index by 5-31% from baseline (P < 0.05) and significantly lowered sys...

Methods 24 post-operative cardiac patients were prospectively enrolled. Arterial pressure and central venous pressure was measured invasively. Cardiac output (CO) was measured with a non-calibrated LiDCOplus monitor (LiDCO, Cambridge). Pmsf was measured using the stop-flow arterial venous equilibrium pressure method (1). Sublingual microcirculation was recorded with CytoCam (Braedius Medical, A...

Microcirculation plays an important role both in physiological and pathophysiological states. Early recognition of changes in microcirculation is crucial for starting early therapeutic intervention and reversing the organ failure. Orthogonal polarization spectral (OPS) and Sidestream dark field imaging (SDF) are relatively new noninvasive methods that allow direct visualisation of the microcirc...

The coronary microcirculation was examined for platelet and fibrin thrombi in hearts from 21 normal subjects and 244 cardiac patients, including 168 with ischemic heart disease (IHD) and 76 with other types of heart disease. Seventy-seven cases were sudden cardiac death (SCD). No microthrombi were present in any of the normal hearts, whereas platelet and fibrin thrombin were present in the coro...

During the course of cirrhosis, a progressive reduction of splanchnic vascular resistance takes place in parallel with a deterioration of cardiac function manifested by the disappearance of the hyperdynamic circulation due to a fall in cardiac output. This compromises arterial pressure and determines a homeostatic activation of endogenous vasoconstrictor systems. Cirrhotic patients are prone to...