Schalij MJ, Bax JJ. Optimal left ventricular lead position predicts reverse remodeling and survival after cardiac resynchronization therapy. J Am Coll Cardiol 2008;52: 1402–1409. 28. Yu Y, Kramer A, Spinelli J, Ding J, Hoersch W, Auricchio A. Biventricular mechanical asynchrony predicts hemodynamic effect of uniand biventricular pacing. Am J Physiol Heart Circ Physiol 2003;285:H2788–H2796. 29. ...

BACKGROUND Cardiac transplantation remains the gold standard for treating end-stage heart failure. However, because of donor shortage and posttransplant complications alternative options are needed. METHODS We investigated the impact of cardiac resynchronization therapy on clinical outcome in 545 patients with left bundle-branch block and interventricular asynchrony, who fulfilled the cardiac...

et al. Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. et al. Multicentre study using strain delay index for predicting response to cardiac resynchronization therapy (MUSIC study). Reverse remodelling induces progressive ventricular resynchronization after cardiac resynchronization therapy 'from vicious to virtuous cycle'...

INTRODUCTION AND OBJECTIVES The effect of cardiac resynchronization therapy on antitachycardia pacing still has to be determined. PATIENTS AND METHOD A total of 490 heart failure patients with an indication for an implantable cardioverter-defibrillator participated in the VENTAK CHF/CONTAK CD study, a single-blind, randomized, placebo-controlled study. We compared antitachycardia pacing effic...

Cardiac dyssynchrony refers to disparity in cardiac wall motion, a serious consequence of myocardial infarction associated with poor outcome. Infarct-induced scar is refractory to device-based cardiac resynchronization therapy, which relies on viable tissue. Leveraging the prospect of structural and functional regeneration, reparative resynchronization has emerged as a potentially achievable st...

OBJECTIVES: To investigate the association between diastolic function and the different beneficial effects of cardiac resynchronization therapy in patients with heart failure due to different causes. METHODS: The 104 enrolled patients were divided into an ischemic cardiomyopathy group (n=27) and a non-ischemic cardiomyopathy group (n=77) according to the cause of heart failure. Before implant...

BACKGROUND Cardiac resynchronization therapy results in improved ejection fraction in patients with heart failure. We sought to determine whether these effects were mediated by changes in contractility, afterload, or volumes. METHODS AND RESULTS In 610 patients with New York Heart Association class I/II heart failure from the Resynchronization Reverses Remodeling in Systolic Left Ventricular ...

Cardiac resynchronization therapy has been an effective option in patients with advanced heart failure. However, 20 to 30% of the patients do not benefit from this therapy. Clinical, electrocardiographic and echocardiographic criteria have been studied in an attempt to select patients who will benefit from a cardiac resynchronization therapy, and the echocardiogram is important both in the sele...

ventricular dyssynchrony on dynamic mitral regurgitation in patients with heart failure due to coronary artery disease. Am J Cardiol 2005; 96:1304–1307. 10. Breithardt OA, Sinha AM, Schwammenthal E, Bidaoui N, Markus KU, Franke A, Stellbrink C. Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure. J Am Coll Cardiol 2003;41:765–...

tion therapy? Guesses and evidence. JACC Heart Fail 2015;3:337–339. 23. Wikstrom BG, Lundqvist CB, Andren B, Lonnerholm S, Blomstrom P, Freemantle N, Remp T, Cleland JG. The effects of aetiology on outcome in patients treated with cardiac resynchronisation therapy in the CARE-HF trial. Eur Heart J 2009;30:782–788. 24. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, Marco TD, Carson P, DiCa...