BACKGROUND Cardiovascular and respiratory diseases are leading causes of morbidity and their co-occurrence has important implications in mortality and other outcomes. Even the most recent guidelines do not reliably address clinical, prognostic, and therapeutic concerns due to the overlap of respiratory and cardiac diseases. STUDY OBJECTIVES AND DESIGN In order to evaluate in the reality of cl...

OBJECTIVE To determine the influence of cardio-pulmonary-bypass-time on hospital mortality and ICU-morbidity in isolated CABG surgery. METHODS Between 1985 and 1994 perioperative data of 8578 consecutive CABG operations were prospectively collected. Seven variables: gender, redo vs. primary operation, elective vs. urgent surgery, age in 4 categories, use of IMA, number of distal anastomoses (...

Skeletal muscle metabolic function is known to respond positively to exercise interventions. Developing non-invasive techniques that quantify metabolic adaptations and identifying interventions that impart successful response are ongoing challenges for research. Healthy non-athletic adults (18-35 years old) were enrolled in a study investigating physiological adaptations to a minimum of 16 week...

Over the past decade, understanding about feedback mechanisms involving the heart, lung and kidney is significantly improved. Each organ injury may trigger hemodynamic, neuro-hormonal and cellular pathway that may damage diverse organs. Recurrent acute on chronic injury may lead to the advanced stage of disease. On the other hand, chronic pathological conditions may decrease functional reserve ...

dear colleagues, welcome to the fourth issue of the journal of cardio-thoracic medicine. we are grateful that with support and cooperation of our dear colleagues, the first year of jctm publication passed successfully. we are expecting to promote the indexing of journal of cardio-thoracic medicine in the following year. in this issue, a valuable review article has been written by dr.corlateanu ...

Cardiovascular diseases are the main causes of mortality and morbidity in Brazil. Their primary and secondary preventions are a priority for the health system and require multiple approaches for increased effectiveness. Biomarkers are tools used to identify with greater accuracy high-risk individuals, establish a faster diagnosis, guide treatment, and determine prognosis. This review aims to hi...

High-density lipoprotein (HDL) cholesterol has been known for ages to be cardio-protective due its defensive action against genesis of atherosclerosis. Increasing the serum HDL (HDL-C) as a prospective potential prevent coronary heart disease could not prove beneficial in human trials that put forward major concern about role and functional contribution HDL-C health. Many observational studies ...

The structure and the functioning of cardio-pulmonary system is complex and statistical physics appear to be suitable for their characterization. In this review, we examine scaling in cardio-pulmonary physiology. The focus will be on the interpretation of scaling behaviors and their relation to structure-function in the normal and diseased cardio-pulmonary system. First, we overview fluctuation...