Examples of toxic cardiomyopathies of various characteristics are presented. Daunomycin and doxorubicin, antineoplastic drugs, cause multifocal cardiomyopathies and intractable heart failure by cardiotoxic mechanisms; these effects are delayed and related to the cumulative dose. Cobalt caused diffuse vacuolar cardiomyopathy in chronic beer drinkers. The development of fulminant heart failure wa...

Mitochondria are found in all nucleated human cells and perform various essential functions, including the generation of cellular energy. Mitochondria are under dual genome control. Only a small fraction of their proteins are encoded by mitochondrial DNA (mtDNA), whereas more than 99% of them are encoded by nuclear DNA (nDNA). Mutations in mtDNA or mitochondria-related nDNA genes result in mito...

background: alcohol consumption has multiple side effects on heart which can be divided to six subgroups: heavy alcohol drinkers (80 g/day alcohol consumption) are most susceptible to cardiac complications. the aim of this study was to review alcohol side effects on heart and two present two alcoholic patients with alcoholic cardiomyopathy. case report: case a: a 52 year-old man presented with ...

background: it is not clear whether the latest activation sites in the left ventricle (lv) are matched with infracted regions in patients with ischemic cardiomyopathy (icm). we aimed to investigate whether the latest activation sites in the lv are in agreement with the region of akinesia in patients with icm.   methods: data were analyzed in 106 patients (age = 60.5 ± 12.1 y, male = 88.7%) with...

background: cardiac resynchronization therapy (crt) is an effective treatment for patients with moderate to severe heart failure. however, 20-30% of patients remain non-responders to crt. we sought to identify which patients benefit the most from crt in regard to the etiology of heart failure. methods: eighty-three consecutive patients (62 men) who had a biventricular pacemaker inserted at tehr...

Infiltrative cardiomyopathies can result from a wide spectrum of both inherited and acquired conditions with varying systemic manifestations. They portend an adverse prognosis, with only a few exceptions (ie, glycogen storage disease), where early diagnosis can result in potentially curative treatment. The extent of cardiac abnormalities varies based on the degree of infiltration and results in...

Cardiomyopathies (CMs) have many etiological factors that can result in severe structural and functional dysregulation. Fortunately, there are several potentially reversible CMs that are known to improve when the root etiological factor is addressed. In this article, we discuss several of these reversible CMs, including tachycardia-induced, peripartum, inflammatory, hyperthyroidism, Takotsubo, ...