نتایج جستجو برای: cask

تعداد نتایج: 486  

Journal: :Neuron 2004
Guey-Shin Wang Chen-Jei Hong Tsen-Yann Yen Hsin-Yi Huang Yvonne Ou Tzyy-Nan Huang Wei-Gang Jung Ting-Yu Kuo Morgan Sheng Ting-Fang Wang Yi-Ping Hsueh

CASK acts as a coactivator for Tbr-1, an essential transcription factor in cerebral cortex development. Presently, the molecular mechanism of the CASK coactivation effect is unclear. Here, we report that CASK binds to another nuclear protein, CINAP, which binds histones and facilitates nucleosome assembly. CINAP, via its interaction with CASK, forms a complex with Tbr-1, regulating expression o...

2010
T. Bullard M. Greiner M. Dennis S. Bays R. Weiner

Preliminary studies of used fuel generated in the US Department of Energy’s Advanced Fuel Cycle Initiative have indicated that current used fuel transport casks may be insufficient for the transportation of said fuel. This work considers transport of three 5-year-cooled oxide advanced burner reactor used fuel assemblies with a burn-up of 160 MWD kg. A transport cask designed to carry these asse...

2012
Meixia Li Shengyun Wen Xiangqian Guo Baoyan Bai Zhefeng Gong Xiaojun Liu Yijin Wang Yanqiong Zhou Xiaowei Chen Li Liu Runsheng Chen

Long non-coding RNAs (lncRNAs) that have no protein-coding capacity make up a large proportion of the transcriptome of various species. Many lncRNAs are expressed within the animal central nervous system in spatial- and temporal-specific patterns, indicating that lncRNAs play important roles in cellular processes, neural development, and even in cognitive and behavioral processes. However, rela...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
J P Borg M O Lõpez-Figueroa M de Taddèo-Borg D E Kroon R S Turner S J Watson B Margolis

A heterotrimeric complex containing Lin-10/X11alpha, Lin-2/CASK, and Lin-7 is evolutionarily conserved from worms to mammals. In Caenorhabditis elegans, it localizes Let-23, a receptor tyrosine kinase, to the basolateral side of vulval epithelium, a step crucial for proper vulva development. In mammals, the complex may also participate in receptor targeting in neurons. Accordingly, phosphotyros...

Journal: :Genetics 2011
Justin B Slawson Elena A Kuklin Aki Ejima Konark Mukherjee Lilly Ostrovsky Leslie C Griffith

Genetic causes for disturbances of locomotor behavior can be due to muscle, peripheral neuron, or central nervous system pathologies. The Drosophila melanogaster homolog of human CASK (also known as caki or camguk) is a molecular scaffold that has been postulated to have roles in both locomotion and plasticity. These conclusions are based on studies using overlapping deficiencies that largely e...

Journal: :The Journal of Cell Biology 1998
Yi-Ping Hsueh Fu-Chia Yang Viktor Kharazia Scott Naisbitt Alexandra R. Cohen Richard J. Weinberg Morgan Sheng

CASK, the rat homolog of a gene (LIN-2) required for vulval differentiation in Caenorhabditis elegans, is expressed in mammalian brain, but its function in neurons is unknown. CASK is distributed in a punctate somatodendritic pattern in neurons. By immunogold EM, CASK protein is concentrated in synapses, but is also present at nonsynaptic membranes and in intracellular compartments. This immuno...

Journal: :تابش و فناوری هسته ای 0
اصغر محمدی دانشگاه آزاد واحد علوم و تحقیقات، تهران، تهران، ایران مصطفی حسن زاده پژوهشکده راکتور، سازمان انرژی اتمی ایران، تهران ، تهران ، ایران مرتضی قریب دانشگاه آزاد واحد علوم و تحقیقات، تهران، تهران، ایران علی مالکی فارسانی سازمان انرژی اتمی ایران ، شرکت پسمانداری صنعت هسته ای ایران، تهران، ایران

in this research, shielding and criticality safety calculations carried out for interim storage and transportation cask in the tehran research reactor. such dual purpose cask is being designed to the spent fuel elements of research reactors. the monte carlo mcnp5 code calculation was utilized for the criticality safety analysis and origen2.1code was used for shielding calculation. according to ...

2014
Konark Mukherjee Justin B. Slawson Bethany L. Christmann Leslie C. Griffith

Modular scaffolding proteins are designed to have multiple interactors. CASK, a member of the membrane-associated guanylate kinase (MAGUK) superfamily, has been shown to have roles in many tissues, including neurons and epithelia. It is likely that the set of proteins it interacts with is different in each of these diverse tissues. In this study we asked if within the Drosophila central nervous...

Journal: :Molecular and Cellular Neuroscience 2011
Kaiyun Chen David E. Featherstone

CASK ('calcium/calmodulin-dependent serine protein kinase'), also known in Drosophila as 'Caki' or 'Camguk/CMG', and in C. elegans as 'Lin-2', is thought to play an important role in cell-cell junction formation and at synapses in particular. To understand the role of CASK in synapse formation and function, we functionally and morphologically analyzed Drosophila embryonic and larval glutamaterg...

2017
Shin Hayashi Daniela Tiaki Uehara Kousuke Tanimoto Seiji Mizuno Yasutsugu Chinen Shinobu Fukumura Jun-Ichi Takanashi Hitoshi Osaka Nobuhiko Okamoto Johji Inazawa

The CASK gene (Xp11.4) is highly expressed in the mammalian nervous system and plays several roles in neural development and synaptic function. Loss-of-function mutations of CASK are associated with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH), especially in females. Here, we present a comprehensive investigation of 41 MICPCH patients, analyzed by mut...

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