نتایج جستجو برای: caspase cascade

تعداد نتایج: 79418  

Journal: :Chemical communications 2012
Kyoungsook Park Jinyoung Jeong Bong Hyun Chung

The real-time monitoring of the caspase cascade in cancer cells during apoptosis was performed using various caspase substrate-linked fluorescent proteins-conjugated gold nanoparticles as a new imaging probe.

Journal: :Circulation 1998
S M Schwartz

The article by Yaoita et al in this issue of Circulation is the first of what will indubitably be many articles on the role of the caspases in cell death. This is an important event. Until 10 years ago, we could not define death at all. Instead, we relied on the process of necrosis, the decay of the cell after its death, as a way to tell us that cells had died. Typical experiments involved appl...

Journal: :Gut 2003
F M Ruemmele S Schwartz E G Seidman S Dionne E Levy M J Lentze

BACKGROUND During the process of tumorigenesis most colon cancer cells acquire resistance to apoptosis. The short chain fatty acid butyrate is well established as an antitumour agent which selectively induces apoptosis in colon cancer cells but not in normal intestinal epithelial cells. AIMS To analyse the signalling pathway of butyrate induced apoptosis. METHODS Using Caco-2 cells we focus...

2012
Hidekazu Kuwayama

Caffeine is a globally consumed psychostimulant but can be fatal to cells at overdose exposures. Although caspase-dependent apoptosis plays a role in caffeine-induced cell death, the responsible intracellular signalling cascade remains incompletely understood. The cellular slime mould, Dictyostelium discoideum, does not possess caspase-dependent apoptotic machinery. Here, we observed that ablat...

Journal: :Neuron 2011
Song Jiao Zheng Li

It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that caspase-3 is activated by the BAD-BAX cascade for LTD induction. This cascade is...

Journal: :Journal of biochemistry and molecular biology 2002
Ssang-Goo Cho Eui-Ju Choi

Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor pro...

2009
Mathieu Kerbiriou Ling Teng Nathalie Benz Pascal Trouvé Claude Férec

In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER). We previously showed that the unfolded protein response (UPR) may be triggered in CF. Since prolonged UPR activation leads to apoptosis via the calcium-calpain-caspase-12-caspase-3 cascade ...

Journal: :Journal of neuropathology and experimental neurology 2004
Hiroshi Takuma Takami Tomiyama Keisuke Kuida Hiroshi Mori

Amyloid beta peptide (A beta) is widely believed to play a central and etiological role in Alzheimer disease (AD). A beta has been shown to have cytotoxic effects in neural cells, although the mechanism by which it does this is still unclear. To examine the involvement of the apoptotic cascade in A beta-induced cell death, we used mice deficient in caspase-3 (CPP 32), a key protease in this cas...

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