a fibroadenoma was diagnosed in the mammary gland of a lamb by immunohistochemical method andmeasurement of oestradiol hormone. the tumor was characterized by an encapsulated firm mass with acreamy-white cut surface. histologically, it consisted of variably-sized sinus ducts, covered by a single ormultiple layers of proliferated epithelial cells, and embedded in a loose connective tissue. immun...

To test the hypothesis that under restricted and surfeit protein intake the mammary gland undergoes adaptive regulation, changes in mammary tissue mRNA abundance of cationic amino acid (AA) transporter (CAT)-1, CAT-2B, alanine/serine/cysteine/threonine transporter 1 (ASCT1), and broad specificity transporter for neutral and cationic AA (ATB(0,+)), and CAT-1 protein abundance were investigated a...

This report describes the handling and clinical evolution of a malignant feline mammary carcinoma (FMC) in an eight-year-old female crossbred cat with congenital disorder. Hence, efficacy tumor mass removal case prognosis was established by postoperative routine histological examination. A 6 cm diameter lump left thoracic gland multinodular appearance purulent exudate reddish hue excised after ...

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

Electron microscopic study of 1 1 spontaneous cat mammary tumors revealed the presence of virus-like particles in 5 of the tumors examined. In three tumors, spherical particles with two concentric shells surrounding an electron-lucent center were found budding from, or free within, the cisternae of the endoplasmic reticulum. In one tumor, spherical particles with four concentric shells surround...

Human ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this gene has been described in HBC. Moreover, it is also recognised that oncogenes that are commonly amplified or deleted encompass point mutations, a...

Electron microscopic study of 1 1 spontaneous cat mammary tumors revealed the presence of virus-like particles in 5 of the tumors examined. In three tumors, spherical particles with two concentric shells surrounding an electron-lucent center were found budding from, or free within, the cisternae of the endoplasmic reticulum. In one tumor, spherical particles with four concentric shells surround...

Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of Wnt signaling in vivo would be extremely useful. By applying chemical inducer of dimerization (CID) technology, we were able to modify the Wnt co-receptor, low-density lipoprotein (LDL)-receptor-re...