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The mechanism and speed of endocytosis at central synapses after neurotransmitter release is still under debate. In this issue of Neuron,Delvendahl et al. (2016) propose an ultrafast form of endocytosis after single action potentials (APs) at physiological temperature.

century, a new era that will be far more scientific, technologic, and sophisticated than anyone would have imagined just a quarter of a century ago. However, the continued success in all areas of pharmaceutical science will depend entirely on how fast pharmaceutical scientists will adapt to rapidly changing technology. Almost 10 years ago, a survey by Shangraw and Demarest revealed a very inter...