The direct and modulating effects of acidosis on catecholamine secretion in rainbow trout (Oncorhynchus mykiss) were assessed in vivo using cannulated fish and in situ using a perfused cardinal vein preparation. In situ, acidosis (a reduction in perfusate pH from 7.9 to 7.4) did not elicit catecholamine release or modulate the secretion of catecholamines evoked by the non-specific cholinergic r...

Marked deficits in glucose availability, or glucoprivation, elicit organism-wide counter-regulatory responses whose purpose is to restore homeostasis. However, while catecholamine neurons of the ventrolateral medulla (VLMCA) are thought orchestrate these responses, circuit and cellular mechanisms underlying specific largely unknown.

Epileptic seizures have been associated with increased catecholamine levels, however, direct proof is lacking. We report a case with catecholamine secreting extra-adrenal paragangliomas and a continuous state of epilepsy not responding to therapy. The epileptic seizures resolved after resection of the paragangliomas and normalization of catecholamine excretion.

Catecholamine-induced cardiomyopathy is characterized by left ventricle apex and mid ventricle wall-motion abnormalities in the absence of coronary artery stenosis. Catecholamine-induced cardiomyopathy is very rare in children. Pheochromocytoma is one of the most important causes of this contractile pattern. Herein we report the case of catecholamine-induced cardiomyopathy in a child with parag...

Cancer is one of the leading causes death in world. Researchers keep attempting to develop therapy modalities decrease mortality and morbidity cancer patients by trying comprehend effect sympathetic nerves (through catecholamine adrenergic receptors) development. Catecholamine activation β-adrenergic receptors (β1-AR, β2-AR, β3-AR) may influence cytokine immunity system, initiate tumorigenesis,...

Aromatic amino acids in the brain function as precursors for the monoamine neurotransmitters serotonin (substrate tryptophan) and the catecholamines [dopamine, norepinephrine, epinephrine; substrate tyrosine (Tyr)]. Unlike almost all other neurotransmitter biosynthetic pathways, the rates of synthesis of serotonin and catecholamines in the brain are sensitive to local substrate concentrations, ...

Increased arachidonic acid release occurred during activation of catecholamine secretion from cultured bovine adrenal medullary chromaffin cells. The nicotinic agonist 1,1-dimethyl-4- phenylpiperazinium (DMPP) caused an increased release of preincubated [3H]arachidonic acid over a time course which corresponded to the stimulation of catecholamine secretion. Like catecholamine secretion, the DMP...

The development of electrochemical recordings with small carbon-fiber electrodes has significantly advanced the understanding of the regulation of catecholamine transmission in various brain areas. Recordings in vivo or in slice preparations monitor diffusion of catecholamine following stimulated synaptic release into the surrounding tissue. This synaptic ‘overflow’ is defined by the amount of ...

Acute catecholamine cardiomyopathy is an uncommon, life-threatening manifestation of pheochromocytoma. The massive release of catecholamines from the adrenal medulla and their toxic effects on the coronary vessels and the cardiac myocytes play a significant role in the pathogenesis of cardiomyopathy in patients with pheochromocytoma. Severe manifestations, such as acute catecholamine cardiomyop...