We present a case of caudal regression syndrome (CRS), a relatively uncommon defect of the lower spine accompanied by a wide range of developmental abnormalities. CRS is closely associated with pregestational diabetes and is nearly 200 times more prevalent in infants of diabetic mothers (1, 2). We report a case of prenatally suspected CRS in a fetus of a nondiabetic mother and discuss how the i...

Caudal regression is a rare syndrome which has a spectrum of congenital malformations ranging from simple anal atresia to absence of sacral, lumbar and possibly lower thoracic vertebrae. It results from a disturbance in the fetal mesoderm in early pregnancy (< 4 week of gestation). Maternal diabetes, genetic predisposition and vascular hypoperfusion have been suggested as possible causative fac...

Objective: To explore prenatal ultrasound diagnosis of VACTERL syndrome and partial caudal regression syndrome. Methods: 60 patients with VACTERL syndrome and partial caudal regression syndrome treated in our hospital during September 2011 to December 2013 were retrospectively analysed. The prenatal sonographic of patient was analysed taking the postpartum result as a standard. Results: Prenata...

OBJECTIVE To describe cases of sirenomelia and severe caudal regression syndrome (CRS), to report the prevalence of sirenomelia, and compare our findings with the literature. METHODS Retrospective data was retrieved from the medical records of infants with the diagnosis of sirenomelia and CRS and their mothers from 1989 to 2010 (22 years) at the Security Forces Hospital, Riyadh, Saudi Arabia....