In pavement design, the CBR and direct shear tests are two very common laboratory investigations for predicting the strength of a subgrade layer. The relationship between the CBR and water content has been commonly presented in analyses, with the result of the direct shear being expressed from the aspect of effective cohesion and the internal friction angle. Even though most natural soil is in...

Objectives: One of the prominent vital needs for implementing a Community-Based Rehabilitation(CBR) program is correct perception and we know that CBR is linked to several challenges. The current study was performed to identify the challenges of implementing a CBR program in Iran based on the perceptions of the stakeholders. Methods: This study was qualitative conventional content analysis. In...

Arterial baroreceptors in the carotid sinus (CBR) and aortic arch (ABR) regions exert important control over heart rate and peripheral vascular responses to changes in arterial pressure. The relative roles of these two baroreflex pathways on control of sympathetic nerve activity during sustained elevation of arterial pressure in man is unknown. We therefore studied the relative contributions of...

BACKGROUND Everolimus combined with endocrine therapy has been proved to be effective among postmenopausal women with hormone receptor-positive human epidermal growth factor receptor-2 negative (HR+/HER2-) metastatic breast cancer (MBC). We aimed to evaluate the efficacy and safety of everolimus plus endocrine therapy in Chinese real-world practice for the first time, and investigate factors as...

This article will introduce abductive case-based reasoning (CBR) and attempt to show that abductive CBR and deductive CBR can be integrated in clinical process and problem solving. Then it provides a unified formalization for integration of abduction, abductive CBR, deduction and deductive CBR. This article also investigates abductive case retrieval and deductive case retrieval using similarity...

PURPOSE This retrospective case-series study evaluated efficacy and safety of Endostar combined with chemotherapy in the treatment of advanced bone and soft tissue sarcomas in stage IV. MATERIALS AND METHODS Forty-seven patients diagnosed with stage IV bone and soft tissue sarcomas and treated with chemotherapy in Tianjin Medical University Cancer Institute & Hospital were reviewed. Of these ...

Overexpression of human epidermal growth factor receptor-2 (HER2) in metastatic breast cancer (MBC) is associated with poor prognosis. This single-arm open-label trial (EGF109491; NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive MBC. The primary endpoint was clinical benefit ra...

The modification of transcriptional regulation is a well-documented evolutionary mechanism in both plants and animals, but post-transcriptional controls have received less attention. The derived hermaphrodite of C. elegans has regulated spermatogenesis in an otherwise female body. The PUF family RNA-binding proteins FBF-1 and FBF-2 limit XX spermatogenesis by repressing the male-promoting prote...

conclusions the results of this study show that applying cbr programs in the rural and remote areas can be effective in improving the qol of people with physical disability. results data were analyzed using spss software. the results demonstrated a significant difference in qol between the two groups (p > 0.002). participants in the cbr program group showed a higher level of qol compared with t...

Case-based reasoning (CBR) solves problems using the already stored knowledge, and captures new knowledge, making it immediately available for solving the next problem. Therefore, CBR can be seen as a method for problem solving, and also as a method to capture new experience and make it immediately available for problem solving. The CBR paradigm has been originally introduced by the cognitive s...