نتایج جستجو برای: cd11b

تعداد نتایج: 4495  

Journal: :Journal of immunology 2002
Ke Zen Yuan Liu Dana Cairo Charles A Parkos

CD11b/CD18-mediated adhesive interactions play a key role in regulating polymorphonuclear leukocytes (PMN)) migration across intestinal epithelium. However, the identity of epithelial ligands for migrating PMN remains obscure. In this study we investigated the role of carbohydrates in mediating adhesive interactions between T84 intestinal epithelial cells and CD11b/CD18 purified from PMN. Fucoi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Chunxing Zheng Qian Yang Chunliang Xu Peishun Shou Jianchang Cao Menghui Jiang Qing Chen Gang Cao Yanyan Han Fengying Li Wei Cao Liying Zhang Li Zhang Yufang Shi Ying Wang

Obesity-associated inflammation is accompanied by the accumulation of adipose tissue macrophages (ATMs), which is believed to predispose obese individuals to insulin resistance. CD11b (integrin αM) is highly expressed on monocytes and macrophages and is critical for their migration and function. We found here that high-fat diet-induced insulin resistance was significantly reduced in CD11b-defic...

Journal: :Journal of immunology 2003
Eiji Esashi Takashi Sekiguchi Hiroaki Ito Shigeo Koyasu Atsushi Miyajima

A vast majority of thymocytes are eliminated during T cell development by apoptosis. However, apoptotic thymocytes are not usually found in the thymus, indicating that apoptotic thymocytes must be eliminated rapidly by scavengers. Although macrophages and dendritic cells are believed to play such role, little is known about scavengers in the thymus. We found that CD4(+)/CD11b(+)/CD11c(-) cells ...

2017
Guoxi Yang Xiaoyong Chen Zhao Yan Qingsheng Zhu Chongfei Yang

Macrophage surface antigen-1 (Mac-1, CD11b/CD18) has been implicated in the regulation of osteoclastogenesis. In the synovial tissues of patients with aseptic loosening after total hip replacement, CD11b was up-regulated, which indicated that CD11b is closely involved in osteolysis around the prosthesis. We found that CD11b, but not CD18, promoted osteoclast (OC) maturation. Here, we show CD11b...

Journal: :Blood 1998
Y Zhang A Harada J B Wang Y Y Zhang S Hashimoto M Naito K Matsushima

We have recently established the culture system to generate dendritic cells (DCs) from murine Lin-c-kit+ bone marrow hematopoietic progenitor cells (HPCs) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) + stem cell factor (SCF) + tumor necrosis factor-alpha (TNF-alpha). We present here the identification of two DC precursor subsets originated from HPCs with the phen...

Journal: :Journal of immunology 2010
Yan-Yan Liu Ling-Cong Sun Jing-Jing Wei Dong Li Ye Yuan Bin Yan Zhi-Hui Liang Hui-Fen Zhu Yong Xu Bo Li Chuan-Wang Song Sheng-Jun Liao Zhang Lei Gui-Mei Zhang Zuo-Hua Feng

Gr-1(+)CD11b(+)F4/80(+) cells play important roles in tumor development and have a negative effect on tumor immunotherapy. So far, the mechanisms underlying the regulation of their immunosuppressive phenotype by classical and alternative macrophage activation stimuli are not well elucidated. In this study, we found that molecules from necrotic tumor cells (NTC-Ms) stimulated Gr-1(+)CD11b(+)F4/8...

Journal: :Molecular & cellular biomechanics : MCB 2006
Meghan H Hoskins Cheng Dong

It has been determined previously that polymorphonuclear leukocytes, or PMNs, can facilitate melanoma cell extravasation through the endothelium under shear conditions. The interactions between melanoma cells and PMNs are mediated by the beta2-integrins expressed by PMNs and intercellular adhesion molecules (ICAM-1) expressed on melanoma cells. In this study, the kinetics of these interactions ...

Journal: :The Journal of clinical investigation 2017
Mohd Hafeez Faridi Samia Q Khan Wenpu Zhao Ha Won Lee Mehmet M Altintas Kun Zhang Vinay Kumar Andrew R Armstrong Carmelo Carmona-Rivera Jessica M Dorschner Abigail M Schnaith Xiaobo Li Yogita Ghodke-Puranik Erica Moore Monica Purmalek Jorge Irizarry-Caro Tingting Zhang Rachael Day Darren Stoub Victoria Hoffmann Shehryar Jehangir Khaliqdina Prachal Bhargava Ana M Santander Marta Torroella-Kouri Biju Issac David J Cimbaluk Andrew Zloza Rajeev Prabhakar Shashank Deep Meenakshi Jolly Kwi Hye Koh Jonathan S Reichner Elizabeth M Bradshaw JianFeng Chen Luis F Moita Peter S Yuen Wanxia Li Tsai Bhupinder Singh Jochen Reiser Swapan K Nath Timothy B Niewold Roberto I Vazquez-Padron Mariana J Kaplan Vineet Gupta

Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chronically increased inflammatory status in patients. T...

Journal: :Journal of immunology 2009
Jian-Ming Li Lauren T Southerland Ying Lu Kataryna A Darlak Cynthia R Giver Douglas W McMillin Wayne A C Harris David L Jaye Edmund K Waller

We investigated the roles of specific subsets of donor APCs purified from bone marrow in donor T cell activation and graft-vs-leukemia (GvL) activity in murine models of hemopoietic stem cell transplantation. Lineage(-)CD11c(+) APC precursors were separated from donor bone marrow based on expression of CD11b. Transplanting lineage(-)CD11c(+)CD11b(-) APC (CD11b(-) APC) in combination with c-kit(...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2007
Albert P Senft Thomas R Korfhagen Jeffrey A Whitsett Ann Marie LeVine

The beta(2)-integrin receptors (CD11a/CD18, CD11b/CD18, and CD11c/CD18) are expressed on the surface of alveolar macrophages and are important for the phagocytic clearance of pathogens. In the present study, we demonstrate that surfactant protein D (SP-D) modulates surface expression of CD11b and CD11c, but not CD11a or CD18, on alveolar macrophages. While cell surface receptors were reduced, C...

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