Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils to release NETs, we examined surgical specimens from CRC to investigate the presence of polyP, as ...

We have recently begun to gain a clearer understanding of the phasing and patterns of colonization of the developing human brain by microglia. In this study we investigated the distribution, morphology and phenotype of microglia specifically within the wall of the human telencephalon from 12 to 24 gestational weeks (gw), a period that corresponds to the development of thalamocortical fibres pas...

Background: Breast cancer is formed of a neoplastic component (epithelial) and a non-neoplastic component (stroma). Stromal- stromal and tumor- stromal interactions have been shown in the regulation of cancer cell growth, metastatic capacity and outcome of treatment. Tumor-associated macrophages (TAMs) are a component of tumor stroma reactionsand are considered as an important ...

BACKGROUND Allergic Contact Dermatitis (ACD) is regarded as a T-cell-mediated delayed-type hypersensitivity reaction. We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis ...

Rosai-Dorfman disease (RDD) is a type of sinus histiocytosis. It rare (1:200000), particularly in children and commonly presents with massive, painless usually bilateral cervical lymphadenopathy along fever weight loss. Leukocytosis, elevated erythrocyte sedimentation rate hypergammaglobulinemia are common. A definitive diagnosis can only be made by histological analysis affected lymph nodes. E...

primary sarcoma of the breast is very rare and constitutes less than 1% of all breast cancers. herein, we report a case of pleomorphic rhabdomyosarcoma (prms) of the right breast in a 49-year-old female patient presented with a mass (7 cm × 6.5 cm). mammography and ultrasonography suspected a malignant lesion and a diagnosis of poorly differentiated carcinoma was made on fine needle aspiration ...

Interleukin (IL)-15 is a pleiotropic immunomodulatory and anti-apoptotic cytokine. It stimulates the proliferation survival of key immunocytes including macrophages (MACs) invariant natural killer T (iNKT) cells, which are immunoinhibitory via IL-10 release clinically relevant in interferon gamma (IFNγ)-mediated inflammatory skin diseases such as alopecia areata. Using immunofluorescence micros...

One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, are unable to dispose of lipoproteins. The present study was undertaken to investigate the characteristics and changes of lysosomes in the earliest stages of the development of atherosclerosis. Electron...

Myeloid sarcoma is a rare extramedullary myeloid tumor, which is frequently misdiagnosed when no evidence of leukemia is initially observed. Here, we report on a peculiar case of a 49-year-old man afflicted with multiple masses in the jejunum, the superior mesentery, and the serosa of the transverse colon, without leukemic manifestation. The tumor was composed of undifferentiated small round ce...

Signalling lymphocytic activation molecule (SLAM, CD150), originally identified as a lymphocyte activation molecule, is now known to be expressed also on mature dendritic cells and on activated monocytes. Importantly, SLAM is distinct from other monocyte activation markers because its expression on monocytes is readily induced in vitro by bacteria derived ligands of Toll-like receptors (TLRs), ...