نتایج جستجو برای: cd8 cd28

تعداد نتایج: 42691  

Journal: :Blood 2007
Edward C P Waller Nicola McKinney Ray Hicks Andrew J Carmichael J G Patrick Sissons Mark R Wills

In healthy carriers of human cytomegalovirus (HCMV), the virus-specific memory CD8(+) T-cell population is often dominated by CD28(-) CD45RA(hi) cells that exhibit direct ex vivo cytotoxicity but whose capacity for proliferation and generation of further memory cells has been questioned. We show that when highly purified CD28(-) CD45RA(hi) CD8(+) T cells are stimulated with viral peptide presen...

2009
Janina Mertens Mario Fabri Alessandra Zingarelli Torsten Kubacki Sonja Meemboor Laura Groneck Jens Seeger Martina Bessler Helena Hafke Margarete Odenthal Joan G. Bieler Christoph Kalka Jonathan P. Schneck Hamid Kashkar Wiltrud M. Kalka-Moll

Zwitterionic capsular polysaccharides (ZPS) of commensal bacteria are characterized by having both positive and negative charged substituents on each repeating unit of a highly repetitive structure that has an alpha-helix configuration. In this paper we look at the immune response of CD8(+) T cells to ZPSs. Intraperitoneal application of the ZPS Sp1 from Streptococcus pneumoniae serotype 1 indu...

Journal: :Journal of immunology 2007
Annie B Borowski Alina C Boesteanu Yvonne M Mueller Caterina Carafides David J Topham John D Altman Stephen R Jennings Peter D Katsikis

CD8(+) T cells are a critical component of the adaptive immune response against infections and tumors. A current paradigm in immunology is that naive CD8(+) T cells require CD28 costimulation, whereas memory CD8(+) T cells do not. We show here, however, that during viral infections of mice, costimulation is required in vivo for the reactivation of memory CD8(+) T cells. In the absence of CD28 c...

Journal: :Journal of immunology 2006
Min Fang Luis J Sigal

Previous studies have suggested that, differing from model Ags, viruses that replicate extensively in the host still induce normal CD8+ T cell responses in the absence of CD28 costimulation. Because these studies were performed with viruses that do not normally cause acute disease, an important remaining question is whether CD28 costimulation is required for CD8+ T cell-mediated resistance to w...

Journal: :Journal of immunology 2005
Mariana Vidric Woong-Kyung Suh Umberto Dianzani Tak W Mak Tania H Watts

CD28, ICOS, and 4-1BB each play distinct roles in the CD8 T cell response to influenza virus. CD28-/- mice are severely impaired in primary CD8 T cell expansion and fail to mount a secondary response to influenza. Influenza-specific CD8 T cells expand normally in ICOS-/- mice, with only a small and transient defect late in the primary response and an unimpaired secondary response. Conversely, 4...

Journal: :The Journal of clinical investigation 1998
A Caruso S Licenziati A D Canaris A Cantalamessa S Fiorentini S Ausenda D Ricotta F Dima F Malacarne A Balsari A Turano

The relationship between the number of circulating CD4+ T cells and the presence of particular CD8+ T cell subsets was analyzed by flow cytometry on PBL from asymptomatic HIV-1-infected patients whose specimens were collected every 2 mo for a total period of 32 mo. Only slight variations were detected in the absolute number of lymphocytes and percentage of CD3+ lymphocytes, whereas both CD4+ an...

Journal: :The Journal of Experimental Medicine 2003
Melanie S. Vacchio Richard J. Hodes

Whereas ligation of CD28 is known to provide a critical costimulatory signal for activation of CD4 T cells, the requirement for CD28 as a costimulatory signal during activation of CD8 cells is less well defined. Even less is known about the involvement of CD28 signals during peripheral tolerance induction in CD8 T cells. In this study, comparison of T cell responses from CD28-deficient and CD28...

Journal: :Journal of virology 2002
Hiroshi Uda Toru Mima Norihiko Yamaguchi Yoshinori Katada Masayuki Fukuda Naohiko Fujii Kojiro Nakamura Osamu Saiki

Infectious mononucleosis (IM) is an acute sporadic infection that usually affects young adults, and during infection a massive expansion of CD8 T cells is generally considered to occur. However, CD28 expression of the expanded cells has not been characterized. When peripheral blood mononuclear cells of acute IM (AIM) patients were analyzed by flow cytometry, a continuous spectrum of CD28 intens...

Journal: :Mediators of Inflammation 2004
Habib Houman Agnes Hamzaoui Imed Ben Ghorbal Monia Smiti Khanfir Moncef Feki Kamel Hamzaoui

BACKGROUND Peripheral blood CD8+ T cells expressing interferon gamma and interleukin-4 (IL-4), and lacking CD28 molecules, were responsible for the dynamic interplay between peripheral blood and inflammatory sites. INTRODUCTION The aim of the current study was to define in Behçet's disease (BD), CD8+ T-cell subsets using CD28 and CD11b monoclonal antibodies, and the characterization of the Tc...

Journal: :Arthritis Research 2002
Michael Schirmer Christian Goldberger Reinhard Würzner Christina Duftner Karl-P Pfeiffer Johannes Clausen Günther Neumayr Albrecht Falkenbach

Circulating CD8(+) CD28(-) T cells were found to be expanded more in patients with ankylosing spondylitis than in an age-matched healthy population (41.2 +/- 17.7% versus 18.6 +/- 7.6%). The level of CD8(+)CD28(-) T cells was dependent on the disease status, but was independent of age. Most of the CD8(+) CD28(-) T cells produced perforin after stimulation in vitro, in contrast to their CD8(+)CD...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید